From the Departments of Radiology.
J Comput Assist Tomogr. 2023;47(2):329-336. doi: 10.1097/RCT.0000000000001411. Epub 2022 Dec 27.
Patients with eosinophilic chronic rhinosinusitis with nasal polyps (eosCRSwNP) usually have more extensive sinus disease, severe symptoms, and poorer disease control compared with patients with non-eosCRSwNP. Separating these entities will be crucial for patient management. The purpose of this study is to investigate T 1, T 2 , and apparent diffusion coefficient (ADC) values of the nasal polyps in patients with CRSwNP and evaluate the usefulness of these parameters for differentiating these diseases.
Sinonasal magnetic resonance imaging was performed in 36 patients with eosCRSwNP and 20 patients with non-eosCRSwNP (including T 1 mapping, T 2 mapping, and diffusion-weighted imaging) before surgery. The T 1 , T 2 , and ADC values were calculated and correlated with pathologically assessed inflammatory cells of nasal polyps.
Significant higher T 2 value, higher eosinophil count, and lower lymphocyte count of the nasal polyps were observed in eosCRSwNP than those in non-eosCRSwNP. There was no significant difference in T 1 or ADC values between the 2 groups. T 2 value was correlated with eosinophil count and lymphocyte count in CRSwNP. The area under the curve of T 2 value for predicting eosCRSwNP was 0.78 with 89.9% sensitivity and 60.0% specificity.
T 2 value is a promising imaging biomarker for predicting eosCRSwNP. It can help to distinguish eosCRSwNP from non-eosCRSwNP.
与非嗜酸粒细胞性慢性鼻-鼻窦炎伴鼻息肉（non-eosCRSwNP）患者相比，嗜酸粒细胞性慢性鼻-鼻窦炎伴鼻息肉（eosCRSwNP）患者通常具有更广泛的鼻窦疾病、更严重的症状和更差的疾病控制。区分这些实体对于患者管理至关重要。本研究旨在探讨鼻窦息肉在 eosCRSwNP 患者中的 T1、T2 和表观扩散系数（ADC）值，并评估这些参数在区分这些疾病方面的有用性。
在手术前，对 36 例 eosCRSwNP 患者和 20 例非 eosCRSwNP 患者（包括 T1 成像、T2 成像和弥散加权成像）进行了鼻旁磁共振成像。计算了 T1、T2 和 ADC 值，并与鼻息肉的病理评估炎性细胞进行了相关性分析。
与非 eosCRSwNP 患者相比，eosCRSwNP 患者的 T2 值更高，鼻息肉中的嗜酸性粒细胞计数更高，淋巴细胞计数更低。两组之间 T1 或 ADC 值无显著差异。T2 值与 CRSwNP 中的嗜酸性粒细胞计数和淋巴细胞计数相关。T2 值预测 eosCRSwNP 的曲线下面积为 0.78，灵敏度为 89.9%，特异性为 60.0%。
T2 值是一种有前途的预测 eosCRSwNP 的影像学生物标志物。它可以帮助区分 eosCRSwNP 与非 eosCRSwNP。
