Ni Ruiqing, Deán-Ben Xosé Luís, Treyer Valerie, Gietl Anton, Hock Christoph, Klohs Jan, Nitsch Roger M, Razansky Daniel
Opt Lett. 2023 Feb 1;48(3):648-651. doi: 10.1364/OL.475578.
Imaging modalities capable of visualizing the human brain have led to major advances in neurology and brain research. Multi-spectral optoacoustic tomography (MSOT) has gained importance for studying cerebral function in rodent models due to its unique capability to map changes in multiple hemodynamic parameters and to directly visualize neural activity within the brain. The technique further provides molecular imaging capabilities that can facilitate early disease diagnosis and treatment monitoring. However, transcranial imaging of the human brain is hampered by acoustic attenuation and other distortions introduced by the skull. Here, we demonstrate non-invasive transcranial MSOT angiography of pial veins through the temporal bone of an adult healthy volunteer. Time-of-flight (TOF) magnetic resonance angiography (MRA) and T-weighted structural magnetic resonance imaging (MRI) were further acquired to facilitate anatomical registration and interpretation. The superior middle cerebral vein in the temporal cortex was identified in the MSOT images, matching its location observed in the TOF-MRA images. These initial results pave the way toward the application of MSOT in clinical brain imaging.
能够可视化人类大脑的成像方式已在神经学和大脑研究中取得了重大进展。多光谱光声断层扫描（MSOT）因其独特的能力，即能够绘制多个血流动力学参数的变化并直接可视化大脑内的神经活动，在啮齿动物模型的脑功能研究中变得越来越重要。该技术还提供分子成像能力，有助于早期疾病诊断和治疗监测。然而，人脑的经颅成像受到颅骨引入的声学衰减和其他失真的阻碍。在此，我们展示了通过一名成年健康志愿者的颞骨对软脑膜静脉进行非侵入性经颅MSOT血管造影。还进一步采集了飞行时间（TOF）磁共振血管造影（MRA）和T加权结构磁共振成像（MRI），以促进解剖配准和解释。在MSOT图像中识别出颞叶皮质中的大脑中浅静脉，与在TOF-MRA图像中观察到的位置相匹配。这些初步结果为MSOT在临床脑成像中的应用铺平了道路。
