Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2023 Jan;174(3):318-321. doi: 10.1007/s10517-023-05699-0. Epub 2023 Feb 1.
The purpose of this study was to find out whether the seminal testosterone and/or estradiol levels could serve as prognostic criteria for normal spermatogenesis and whether they are able to characterize the sperm pathology. The study involved healthy young male volunteers (n=269); serum and seminal steroid hormones were measured; the sperm concentration, mobility, and morphology were evaluated. The results indicate that the seminal testosterone concentration is lower (p<0.05) and the seminal estradiol is higher than the corresponding parameters in the serum (p<0.05). The seminal testosterone and estradiol concentrations negatively correlated with the sperm concentration, and the seminal estradiol concentration was higher in pathozoospermic than in normospermic men (p<0.05). It is assumed that the seminal estradiol level can be an indicator of sperm quality and serve as a biological predictor of normal spermatogenesis; in addition, this parameter can be used for diagnostic purposes in patients with impaired spermatogenesis induced by excess of estrogens.
本研究旨在探讨精液睾酮和/或雌二醇水平是否可用作正常精子发生的预后标准，以及它们是否能够描述精子病理学特征。该研究纳入了 269 名健康年轻男性志愿者；检测血清和精液类固醇激素；评估精子浓度、活力和形态。结果表明，精液睾酮浓度较低（p<0.05），而雌二醇浓度高于血清中的相应参数（p<0.05）。精液睾酮和雌二醇浓度与精子浓度呈负相关，且病理型精子症患者的精液雌二醇浓度高于正常精子症患者（p<0.05）。因此，推测精液雌二醇水平可作为精子质量的指标，并可作为正常精子发生的生物学预测因子；此外，该参数可用于因雌激素过多导致的精子发生障碍患者的诊断目的。
