Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin St, STE MSB 2112, Houston, TX, USA.
Section of Infectious Diseases, Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
J Neurovirol. 2023 Feb;29(1):94-99. doi: 10.1007/s13365-023-01113-7. Epub 2023 Feb 1.
The diagnosis of progressive multifocal leukoencephalopathy (PML) is based on a combination of clinical, radiographic, and laboratory findings. However, negative JC polyomavirus (JCPyV) PCR in CSF does not always rule out JCPyV-related PML. In this narrative review, we sought to examine the characteristic of biopsy-proven PML in patients with undetectable JCPyV CSF PCR and provide alternative approaches in this scenario.
进行进行性多灶性白质脑病（PML）的诊断基于临床、影像学和实验室检查结果的综合判断。然而，CSF 中阴性的 JC 多瘤病毒（JCPyV）PCR 并不能总是排除 JCPyV 相关的 PML。在这篇叙述性综述中，我们试图研究 CSF JCPyV PCR 检测不出的活检证实的 PML 患者的特征，并提供这种情况下的替代方法。
