Department of Communication Sciences and Disorders, University of North Carolina, Greensboro, United States.
Int Tinnitus J. 2022 Dec 1;26(2):79-88. doi: 10.5935/0946-5448.20220012.
To examine the differences in auditory evoked cortical responses that may underlie the tendency of some people to perceive tinnitus. The study hypothesis is that the mean ALR and P300 amplitudes in normal hearing adults who perceive temporary tinnitus after exposure to sustained silence will be larger than the mean ALR and P300 amplitudes in normal hearing adults who do not perceive temporary tinnitus after exposure to sustained silence.
This was a prospective cross-sectional study. The approval for the study was obtained from the IRB and COVID ramp up committee of University of North Carolina Greensboro (UNCG). Participants completed comprehensive hearing screening and preand postsilence ALR and P300 recordings were obtained. After the first ALR/P300 recording participants were exposed to ten minutes of silence. Participants completed a Qualtrics questionnaire to report any tinnitus perception that emerged during silence exposure. Absolute N1, P2 and P300 waveform amplitudes and latencies were identified and were entered into an SPSS spreadsheet for data analysis.
Thirty adult females with normal pure tone hearing thresholds and no history of persistent tinnitus were included in the study. The mean age of the participants was 22.5 ± 3.9 years. When exposed to silence, eight (26.7%) participants perceived temporary tinnitus. N1 and P300 waveforms were smaller in amplitude and faster in latency in the tinnitus perception group; however, the ALR and P300 waveform latencies and amplitudes did not statistically differ significantly between the participants who perceived temporary tinnitus in silence and those who did not (p>0.05). The difference in waveform morphology between the tinnitus perception group and the non-tinnitus perception group revealed a greater difference in P300 amplitude after exposure to silence.
Differences in ALR and P300 latencies and amplitudes were observed between the tinnitus perception group and non-tinnitus perception group, with smaller P300 amplitudes appearing in the group perceiving tinnitus. While the results did not statistically significant, this pattern may reflect a mismatch between the neuronal response in the auditory cortex (N1 and P2 amplitudes and latencies) and the neuronal activity in the modulatory network regions (P300).
研究听觉诱发电皮质反应的差异，这些差异可能是导致某些人感知耳鸣的原因。本研究假设，在暴露于持续静音后感知到短暂耳鸣的正常听力成年人的平均 ALR 和 P300 幅度，将大于在暴露于持续静音后未感知到短暂耳鸣的正常听力成年人的平均 ALR 和 P300 幅度。
这是一项前瞻性的横断面研究。北卡罗来纳大学格林斯伯勒分校（UNCG）的 IRB 和 COVID 加速委员会批准了该研究。参与者完成了全面的听力筛查，并获得了静默前和静默后的 ALR 和 P300 记录。在第一次 ALR/P300 记录后，参与者暴露于十分钟的静音中。参与者完成了一个 Qualtrics 问卷，报告在静音暴露期间出现的任何耳鸣感知。确定了绝对 N1、P2 和 P300 波形幅度和潜伏期，并将其输入到 SPSS 电子表格中进行数据分析。
研究纳入了 30 名具有正常纯音听力阈值且无持续性耳鸣病史的成年女性。参与者的平均年龄为 22.5 ± 3.9 岁。当暴露于静音时，有 8 名（26.7%）参与者感知到短暂耳鸣。在耳鸣感知组中，N1 和 P300 波形的幅度较小，潜伏期较短；然而，在静默时感知到短暂耳鸣的参与者和未感知到短暂耳鸣的参与者之间，ALR 和 P300 波形的潜伏期和幅度没有统计学上的显著差异（p>0.05）。在耳鸣感知组和非耳鸣感知组之间的波形形态差异中，暴露于静音后 P300 幅度的差异更大。
在耳鸣感知组和非耳鸣感知组之间观察到 ALR 和 P300 潜伏期和幅度的差异，在感知耳鸣的组中 P300 幅度较小。虽然结果没有统计学意义，但这种模式可能反映了听觉皮层（N1 和 P2 幅度和潜伏期）中的神经元反应与调制网络区域（P300）中的神经元活动之间的不匹配。
