Thyssen Jacob P, Nymand Lea K, Maul Julia-Tatjana, Schmid-Grendelmeier Peter, Wu Jashin J, Frøstrup Anne Grete, Gren Susanne Thiesen, Thomsen Simon Francis, Egeberg Alexander
From the Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dermatitis. 2023 Sep-Oct;34(5):432-439. doi: 10.1089/derm.2022.0036. Epub 2023 Feb 1.
There is currently limited insight into the broader impact of atopic dermatitis (AD) on mental health. Although studies indicate that AD patients may experience fatigue, no study has so far examined fatigue in more granular detail, for example, occurrence of general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue, or correlated fatigue measures with AD severity and symptoms intensity. To examine fatigue subtypes and their prevalence in adults with AD, as well as their possible association with AD severity. A survey was conducted in adults with AD who had been managed in a hospital setting. The Patient-Oriented SCORing Atopic Dermatitis was used to determine AD severity. Patient reported outcomes, including multidimensional fatigue inventory, were included. Data from 2729 adults with AD were analyzed. The total and individual fatigue scores increased consistently with lower socioeconomic scores, higher AD severity, Dermatology Life Quality Index, itch, pain, and sleep scores. Increased fatigue scores were associated with AD severity in adjusted analyses. Among adults with AD, fatigue scores increased with disease severity as well as intensity of AD symptoms. Fatigue is a hitherto underappreciated symptom of AD that clinicians should be cognizant about.
目前，对于特应性皮炎（AD）对心理健康的更广泛影响了解有限。尽管研究表明AD患者可能会出现疲劳，但迄今为止尚无研究对疲劳进行更细致的考察，例如，全身性疲劳、身体疲劳、活动减少、动力下降和精神疲劳的发生情况，或者将疲劳指标与AD严重程度及症状强度相关联。为了研究成人AD患者疲劳亚型及其患病率，以及它们与AD严重程度的可能关联。对在医院接受治疗的成人AD患者进行了一项调查。采用以患者为导向的特应性皮炎评分来确定AD严重程度。纳入了患者报告的结局，包括多维疲劳量表。对2729例成人AD患者的数据进行了分析。总体和个体疲劳评分随着社会经济得分降低、AD严重程度增加、皮肤病生活质量指数、瘙痒、疼痛和睡眠评分升高而持续增加。在调整分析中，疲劳评分增加与AD严重程度相关。在成人AD患者中，疲劳评分随着疾病严重程度以及AD症状强度的增加而升高。疲劳是AD一种迄今未得到充分认识的症状，临床医生应予以关注。
