与产后甲状腺功能减退相关的HLA - DR因素：桥本甲状腺炎的早期表现？

HLA-DR factors associated with postpartum hypothyroidism: an early manifestation of Hashimoto's thyroiditis?

作者信息

Pryds O, Lervang H H, Kristensen H P, Jakobsen B K, Svejgaard A

机构信息

Department of Paediatrics, Central Hospital of Naestved, Denmark.

出版信息

Tissue Antigens. 1987 Jul;30(1):34-7. doi: 10.1111/j.1399-0039.1987.tb01593.x.

DOI:10.1111/j.1399-0039.1987.tb01593.x

PMID:3672491

Abstract

Thirty-three Danish women selected from a prospective study of postpartum thyroiditis were HLA-DR typed. All women had positive titers of antimicrosomal antibodies, and 20 women developed thyroid dysfunction after delivery. DR5 and the phenotype 4.5 were significantly increased in the whole group (p less than 0.001) and strongly associated to hypothyroidism (p less than 0.01), whereas DR3 was insignificantly increased in thyrotoxic women. It is concluded that postpartum hypothyroidism is an autoimmune disorder and may be an early manifestation of Hashimoto's thyroiditis.

摘要

从一项关于产后甲状腺炎的前瞻性研究中选取了33名丹麦女性进行HLA-DR分型。所有女性的抗微粒体抗体滴度均为阳性，20名女性在分娩后出现了甲状腺功能障碍。DR5和表型4.5在整个组中显著增加（p小于0.001），并与甲状腺功能减退密切相关（p小于0.01），而DR3在甲状腺毒症女性中增加不显著。得出的结论是，产后甲状腺功能减退是一种自身免疫性疾病，可能是桥本甲状腺炎的早期表现。