Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Intern Med. 2023 Oct 1;62(19):2895-2900. doi: 10.2169/internalmedicine.1001-22. Epub 2023 Feb 1.
A 72-year-old woman was admitted to our hospital with numbness in her lower extremities and hypereosinophilia. She was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). On admission, she was suspected of being complicated with pneumonia and sepsis; therefore, treatment with mepolizumab monotherapy was begun, resulting in partial improvement. After the possibility of a complicating infection was ruled out, corticosteroids were initiated, followed by intravenous gamma globulin therapy. Although the induction of remission of EGPA with mepolizumab monotherapy is not usually recommended, induction with mepolizumab monotherapy may be an option in terms of safety and clinical efficacy in some cases.
一位 72 岁女性因下肢麻木和嗜酸性粒细胞增多症而入院。她被诊断为嗜酸性肉芽肿性多血管炎（EGPA）。入院时，她被怀疑并发肺炎和败血症；因此，开始使用美泊利珠单抗单药治疗，部分缓解。排除合并感染的可能性后，开始使用皮质类固醇，随后进行静脉注射丙种球蛋白治疗。虽然通常不建议使用美泊利珠单抗单药诱导 EGPA 缓解，但在某些情况下，从安全性和临床疗效的角度来看，美泊利珠单抗单药诱导可能是一种选择。
