Hobara T, Kobayashi H, Kawamoto T, Iwamoto S, Sakai T
Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan.
Toxicol Appl Pharmacol. 1987 Nov;91(2):256-65. doi: 10.1016/0041-008x(87)90106-2.
In order to examine the intestinal absorption of trichloroethylene (TRI), we developed the intestinal circulation system of dogs and administered TRI solution at three concentrations (0.1, 0.25 and 0.5%) to the three parts of the intestinal tract (jejunum, ileum, and colon) of the operated dogs. We measured TRI and its metabolites, free-trichloroethanol, trichloroacetic acid, and conjugated trichloroethanol, in serum or blood, urine, bile and circulating solutions. The absorption rates of TRI from the intestine were 50-70% of the administered volume of TRI 2 hr after administration in all groups, and all parts of intestine readily absorbed TRI. Moreover, there were no significant differences in the absorption rates of TRI and water between the jejunum and ileum, and ileum and colon, respectively. The excretion rates of TRI and its metabolites in urine and bile were very low (0.1-0.4%) compared with the volume of absorbed TRI from the intestine 2 hr after administration in all groups. The high degree of absorption of TRI should be considered when threshold limits for TRI in the drinking water, the surface water, and the ground water are established.
为了研究三氯乙烯（TRI）的肠道吸收情况，我们开发了犬肠道循环系统，并将三种浓度（0.1%、0.25%和0.5%）的TRI溶液分别给予手术犬肠道的三个部位（空肠、回肠和结肠）。我们测定了血清或血液、尿液、胆汁和循环溶液中的TRI及其代谢产物，即游离三氯乙醇、三氯乙酸和结合态三氯乙醇。给药2小时后，所有组中肠道对TRI的吸收率均为给药量的50 - 70%，且肠道各部位均能轻易吸收TRI。此外，空肠与回肠之间以及回肠与结肠之间TRI和水的吸收率分别无显著差异。与给药2小时后肠道吸收的TRI量相比，所有组中TRI及其代谢产物在尿液和胆汁中的排泄率都非常低（0.1 - 0.4%）。在确定饮用水、地表水和地下水中TRI的阈值时，应考虑TRI的高吸收率。
