犬体内三氯乙烯及其代谢产物的胆汁排泄

Biliary excretion of trichloroethylene and its metabolites in dogs.

作者信息

Hobara T, Kobayashi H, Kawamoto T, Sato T, Iwamoto S, Hirota S, Sakai T

出版信息

Toxicol Lett. 1986 Jul-Aug;32(1-2):119-22. doi: 10.1016/0378-4274(86)90057-3.

Abstract

To examine the biliary excretion of trichloroethylene (TRI) and its metabolites, we carried out various experiments with TRI and its metabolites, i.e., chloral hydrate (CH), free-trichloroethanol (F-TCE) and trichloroacetic acid (TCA), using anesthetized dogs. The amount of biliary excretion was significantly increased with the administration of CH and F-TCE, whereas it remained at control levels with the administration of TRI and TCA. The substances excreted into bile were conducted in the form of conjugated-TCE (Conj-TCE) in over 90% of the CH, F-TCE and TRI administration groups. About 95% of these Conj-TCE were conjugated with glucuronic acid. The cumulative excretion ratios of substances and metabolites to dose were 20% for CH and F-TCE, and about 1% for TCA and TRI 2 h after administration.

摘要

为研究三氯乙烯（TRI）及其代谢产物的胆汁排泄情况，我们使用麻醉犬对TRI及其代谢产物，即水合氯醛（CH）、游离三氯乙醇（F-TCE）和三氯乙酸（TCA）进行了各种实验。给予CH和F-TCE后，胆汁排泄量显著增加，而给予TRI和TCA后，胆汁排泄量维持在对照水平。在超过90%的CH、F-TCE和TRI给药组中，排泄到胆汁中的物质以结合型三氯乙烯（Conj-TCE）的形式存在。这些Conj-TCE中约95%与葡萄糖醛酸结合。给药2小时后，物质和代谢产物的累积排泄率占给药剂量的比例，CH和F-TCE为20%，TCA和TRI约为1%。