Liang Xiao, Li Ya-Lan, Zhang Jun-Hao, Bai Hao-Tian, Sun Shu-Hui, Zhang Qian-Qian, Yang Jing, Wang Rui
College of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150040, China.
Basic Medical College, Heilongjiang University of Chinese Medicine Harbin 150040, China.
Zhongguo Zhong Yao Za Zhi. 2023 Jan;48(1):13-21. doi: 10.19540/j.cnki.cjcmm.20221013.601.
Rheumatoid arthritis(RA) is a chronic degenerative joint disease characterized by inflammation. Due to the complex causes, no specific therapy is available. Non-steroidal anti-inflammatory agents and corticosteroids are often used(long-term, oral/injection) to interfere with related pathways for reducing inflammatory response and delaying the progression of RA, which, however, induce many side effects. Microneedle, an emerging transdermal drug delivery system, is painless and less invasive and improves drug permeability. Thus, it is widely used in the treatment of RA and is expected to be a new strategy in clinical treatment. This paper summarized the application of microneedles in the treatment of RA, providing a reference for the development of new microneedles and the expansion of its clinical application.
类风湿性关节炎（RA）是一种以炎症为特征的慢性退行性关节疾病。由于病因复杂，目前尚无特效疗法。非甾体抗炎药和皮质类固醇经常（长期、口服/注射）用于干扰相关途径以减轻炎症反应并延缓RA的进展，然而，这些药物会引发许多副作用。微针作为一种新兴的经皮给药系统，无痛且侵入性小，还能提高药物渗透性。因此，它被广泛应用于RA的治疗，并有望成为临床治疗的新策略。本文综述了微针在RA治疗中的应用，为新型微针的研发及其临床应用的拓展提供参考。
