Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India.
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (Niper), Guwahati, India.
Expert Opin Drug Deliv. 2022 Apr;19(4):395-407. doi: 10.1080/17425247.2022.2053674. Epub 2022 Mar 23.
The current drug therapies for treating rheumatoid arthritis (RA) include nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, or biological products designed to mitigate the symptoms of the disease. These therapies with conventional delivery systems possess limitations such as lack of selectivity and adverse effects in the extra-articular tissues. Microneedles-based transdermal drug delivery gained huge attention that can overcome the limitations associated with conventional preparations.
This review aims to provide detailed information on types of microneedles (MNs) and their usage in drug delivery for the management of RA. In addition, it also provides evidence for the effective use of MNs in RA treatment. Various types of MNs, their regulatory status, clinical trials, and patents are also compiled in this review.
Microneedles are small patch-like structures consisting of needles in micron range arranged in array-like structure used to manage drugs designed to be given via transdermal route. Microneedles provide painless delivery, fast onset of action, bypass the first-pass metabolism, and be easily self-administered. In the case of RA treatment, which requires a long-term application of drugs, MN is a new and emerging way to ease the symptoms of RA.
目前治疗类风湿关节炎（RA）的药物疗法包括非甾体抗炎药、改善病情抗风湿药或旨在减轻疾病症状的生物制品。这些具有常规输送系统的疗法存在缺乏选择性和在关节外组织中产生不良反应等局限性。基于微针的经皮药物输送引起了广泛关注，它可以克服与常规制剂相关的局限性。
本文旨在提供关于微针（MNs）类型及其在 RA 管理中用于药物输送的详细信息。此外，还提供了 MN 在 RA 治疗中有效应用的证据。本文还编译了各种类型的微针、其监管状况、临床试验和专利。
微针是由微米范围内的针组成的小贴片状结构，排列成类似阵列的结构，用于管理设计通过经皮途径给予的药物。微针提供无痛输送、快速起效、绕过首过代谢，并易于自我给药。在需要长期应用药物治疗 RA 的情况下，MN 是一种缓解 RA 症状的新出现的方法。
