Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, P. R. China.
Laboratory Animal Center, Hangzhou Normal University, Hangzhou 311121, P. R. China.
ACS Biomater Sci Eng. 2023 Feb 13;9(2):821-830. doi: 10.1021/acsbiomaterials.2c01539. Epub 2023 Feb 1.
Despite its promising potential in cancer treatment, synergistic photothermal/chemodynamic therapy remains underdeveloped with regard to the utilization of metal-organic materials under second near-infrared (NIR-II) laser excitation. Herein, we report a three-dimensional network constructed via the metal coordination between catechol-functionalized aza-boron dipyrromethenes and iron ions (), which was further encapsulated by F127 to obtain nanoparticles (NPs) for combined photothermal/chemodynamic therapy. NPs exhibited intense absorption in the NIR-II range and negligible fluorescence. Upon 1064 nm laser irradiation, NPs showed high photothermal conversion efficiency (PCE = 55.0%) and excellent photothermal stability. The results of electron spin resonance spectra and -phenylenediamine chromaticity spectrophotometry proved that NPs were capable of generating harmful reactive oxygen species from hydrogen peroxide for chemodynamic therapy, which was promoted by photothermal performance. Notably, and experiments demonstrated the great potential of NPs in photoacoustic imaging and photothermal-enhanced chemodynamic therapy under NIR-II laser irradiation. Therefore, the current work presents a prospective NIR-II excitation therapeutic nanomedicine for combination therapy, offering a novel strategy for simultaneously achieving extended NIR absorption of aza-BODIPY and enhanced chemodynamic therapy with metal-organic materials.
尽管在癌症治疗方面具有广阔的应用前景，但在利用金属有机材料进行近红外二区（NIR-II）激光激发的协同光热/化学动力学治疗方面，仍有很大的发展空间。在此，我们报道了一种通过儿茶酚功能化的氮杂卟啉与铁离子之间的金属配位构建的三维网络（），并进一步通过 F127 对其进行封装，得到用于联合光热/化学动力学治疗的纳米粒子（NPs）。NPs 在 NIR-II 范围内表现出强烈的吸收和可忽略的荧光。在 1064nm 激光照射下，NPs 表现出高光热转换效率（PCE=55.0%）和优异的光热稳定性。电子顺磁共振谱和邻苯二胺比色分光光度法的结果证明，NPs 能够从过氧化氢中产生用于化学动力学治疗的有害活性氧，这一过程受到光热性能的促进。值得注意的是，细胞毒性和体内实验证明了 NPs 在 NIR-II 激光照射下的光声成像和光热增强化学动力学治疗的巨大潜力。因此，本工作提出了一种有前景的 NIR-II 激发治疗性纳米医学，用于联合治疗，为同时实现氮杂 BODIPY 的扩展 NIR 吸收和金属有机材料增强的化学动力学治疗提供了一种新策略。
