Hong Liquan, Ye Jingtao, Li Yang, Yin Shouchun
Deqing Hospital of Hangzhou Normal University, The Third People's Hospital of Deqing Deqing 313200 China
Key Laboratory of Organosilicon Chemistry and Materials Technology of Ministry of Education, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University Hangzhou 311121 China.
RSC Adv. 2024 Oct 17;14(45):32818-32826. doi: 10.1039/d4ra06965j.
The alarming escalation in cancer incidence and mortality has thrust into spotlight the quest for groundbreaking therapeutic strategies. Our research delves into the potential of RDIR780, a novel class of biomimetic nanoparticles cloaked in red blood cell membranes, to significantly enhance their persistence and therapeutic potency. Through an exhaustive suite of experiments, we have charted the therapeutic horizons of RDIR780 in the realms of tumor photothermal synergistic immunotherapy and targeted drug delivery. Preliminary cellular assays have revealed that RDIR780 not only achieves remarkable uptake by tumor cells but also triggers swift tumor cell death under the influence of laser irradiation. Subsequent fluorescence imaging studies have corroborated the nanoparticles' propensity for tumor-specific accumulation, thereby bolstering the case for precision medicine. The results of the precise imaging techniques of therapeutic trials conducted on mice with implanted tumors have underscored the profound impact of RDIR780 when synergized with an anti-PD-L1 antibody. This synergistic approach has shown to fairly eradicate tumor growth, marking a significant stride in the battle against cancer. This pioneering endeavor not only lays down a formidable groundwork for the evolution of long-circulating photothermal therapeutic nanoparticles but also heralds a new era of transformative clinical interventions.
癌症发病率和死亡率的惊人攀升使寻求突破性治疗策略成为焦点。我们的研究深入探讨了RDIR780的潜力，这是一类新型的包裹在红细胞膜中的仿生纳米颗粒，有望显著提高其持久性和治疗效力。通过一系列详尽的实验，我们描绘了RDIR780在肿瘤光热协同免疫疗法和靶向药物递送领域的治疗前景。初步细胞实验表明，RDIR780不仅能被肿瘤细胞大量摄取，还能在激光照射下迅速引发肿瘤细胞死亡。随后的荧光成像研究证实了纳米颗粒具有肿瘤特异性积累的倾向，从而支持了精准医学的理念。对植入肿瘤的小鼠进行治疗试验的精确成像技术结果强调了RDIR780与抗PD-L1抗体协同作用时的深远影响。这种协同方法已显示出能相当程度地根除肿瘤生长，标志着抗癌斗争中的重大进展。这一开创性的努力不仅为长效光热治疗纳米颗粒的发展奠定了坚实基础，也预示着变革性临床干预的新时代的到来。
