Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Department of Health Economics, Erasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Pharmacoeconomics. 2023 Sep;41(9):1137-1149. doi: 10.1007/s40273-022-01233-8. Epub 2023 Feb 1.
Costs of informal care are ignored in many cost-effectiveness analyses (CEAs) conducted from a societal perspective; however, these costs are relevant for lifesaving interventions targeted at the older population. In this study, we estimated informal care costs by age and proximity to death across European regions and showed how these estimates can be included in CEAs.
We estimated informal care costs by age and proximity to death using generalised linear mixed-effects models. For this, we selected deceased singles from the Survey of Health, Ageing and Retirement, which we grouped by four European regions. We combined the estimates of informal care costs with life tables to illustrate the impact of including informal care costs on the incremental cost-effectiveness ratio (ICER) of a hypothetical intervention that prevents a death at different ages.
Informal care use, and hence informal care costs, increase when approaching death and with increasing age. The impact of including informal care costs on the ICER varies between €200 and €17,700 per quality-adjusted life-year gained. The impact increases with age and is stronger for women and in southern European countries.
Our estimates of informal care costs facilitate including informal care costs in CEAs of life-extending healthcare interventions. Including these costs may influence decisions as it leads to reranking of life-extending interventions compared with interventions improving quality of life.
从社会角度进行的许多成本效益分析(CEA)忽略了非正式护理的成本;然而,这些成本对于针对老年人口的救生干预措施是相关的。在这项研究中,我们按年龄和接近死亡的程度估算了欧洲各地区的非正式护理成本,并展示了如何将这些估算纳入 CEA。
我们使用广义线性混合效应模型按年龄和接近死亡的程度估算非正式护理成本。为此,我们从健康、衰老和退休调查中选择了已故的单身人士,并将他们按四个欧洲地区进行分组。我们将非正式护理成本的估算与生命表相结合,以说明包括非正式护理成本对预防不同年龄死亡的假设干预措施的增量成本效益比(ICER)的影响。
随着接近死亡和年龄的增长,非正式护理的使用,从而非正式护理的成本也会增加。包括非正式护理成本对 ICER 的影响在每获得一个质量调整生命年的 200 欧元至 17700 欧元之间变化。影响随着年龄的增长而增加,对女性和南欧国家的影响更大。
我们对非正式护理成本的估算有助于将非正式护理成本纳入延长生命的医疗保健干预措施的 CEA。包括这些成本可能会影响决策,因为它会导致与提高生活质量的干预措施相比,对延长生命的干预措施进行重新排序。