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Gonadotropin releasing hormone (GnRH): a hormone therapy boosts cognition in Down syndrome and dementia.

作者信息

Sterling Keenan, Cao Ruixue, Song Weihong

机构信息

Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada.

The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.

出版信息

Signal Transduct Target Ther. 2023 Feb 1;8(1):49. doi: 10.1038/s41392-023-01321-x.

DOI:10.1038/s41392-023-01321-x
PMID:36725840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9892018/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfee/9892018/760238f0a4f1/41392_2023_1321_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfee/9892018/760238f0a4f1/41392_2023_1321_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfee/9892018/760238f0a4f1/41392_2023_1321_Fig1_HTML.jpg

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Gonadotropin releasing hormone (GnRH): a hormone therapy boosts cognition in Down syndrome and dementia.促性腺激素释放激素(GnRH):一种激素疗法可提高唐氏综合征和痴呆症患者的认知能力。
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GnRH Therapy may Improve Cognitive Function in Down Syndrome.促性腺激素释放激素疗法可能改善唐氏综合征患者的认知功能。
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Targeting the hypothalamus for modeling age-related DNA methylation and developing OXT-GnRH combinational therapy against Alzheimer's disease-like pathologies in male mouse model.针对下丘脑进行建模以研究与年龄相关的 DNA 甲基化,并开发针对男性小鼠模型中阿尔茨海默病样病理的 OXT-GnRH 联合治疗方法。
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本文引用的文献

1
GnRH replacement rescues cognition in Down syndrome.GnRH 替代疗法可改善唐氏综合征患者的认知功能。
Science. 2022 Sep 2;377(6610):eabq4515. doi: 10.1126/science.abq4515.
2
USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation.USP25 抑制通过调节 APP 加工和 Aβ 生成改善阿尔茨海默病病理。
J Clin Invest. 2022 Mar 1;132(5). doi: 10.1172/JCI152170.
3
The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia.人类基底神经节中神秘的促性腺激素释放激素神经元系统。
Elife. 2021 Jun 15;10:e67714. doi: 10.7554/eLife.67714.
4
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.专家共识文件:先天性低促性腺激素性性腺功能减退症的欧洲共识声明——发病机制、诊断和治疗。
Nat Rev Endocrinol. 2015 Sep;11(9):547-64. doi: 10.1038/nrendo.2015.112. Epub 2015 Jul 21.
5
Olfactory impairment increases as a function of age in persons with Down syndrome.唐氏综合征患者的嗅觉障碍会随着年龄的增长而加重。
Neurobiol Aging. 2002 Jan-Feb;23(1):65-73. doi: 10.1016/s0197-4580(01)00263-9.