Centre for Research on Ageing, Health and Wellbeing, Australian National University, 54 Mills Road, Canberra, ACT, 2601, Australia.
Discipline of Psychology, Faculty of Health, University of Canberra, Canberra, ACT, 2617, Australia.
Sci Rep. 2023 Feb 1;13(1):1874. doi: 10.1038/s41598-023-27913-9.
Sleep is an emerging risk factor for dementia but its association with brain health remains unclear. This study included UK Biobank (n = 29,545; mean age = 54.65) participants at imaging visit with sleep measures and brain scans, and a subset (n = 14,206) with cognitive measures. Multiple linear regression analyses were conducted to study the associations between sleep and brain health. Every additional hour of sleep above 7 h/day was associated with 0.10-0.25% lower brain volumes. In contrast, a negative non-linear association was observed between sleep duration, grey matter, and hippocampal volume. Both longer (> 9 h/day) and shorter sleep (< 6 h/day) durations were associated with lower brain volumes and cognitive measures (memory, reaction time, fluid intelligence). Additionally, daytime dozing was associated with lower brain volumes (grey matter and left hippocampus volume) and lower cognitive measures (reaction time and fluid intelligence). Poor sleep (< 6 h/day, > 9 h/day, daytime dozing) at midlife was associated with lower brain health. Sleep may be an important target to improve brain health into old age and delay the onset of dementia.
睡眠是痴呆的一个新出现的风险因素，但它与大脑健康的关系仍不清楚。本研究纳入了 UK Biobank 的影像学检查参与者（n=29545；平均年龄=54.65 岁），这些参与者有睡眠测量和脑部扫描数据，其中一部分参与者（n=14206）还有认知测量数据。采用多元线性回归分析研究睡眠与大脑健康之间的关系。每天睡眠时间比 7 小时多 1 小时，大脑体积会减少 0.10%-0.25%。相比之下，睡眠时间与灰质和海马体体积之间存在负相关的非线性关系。睡眠时间过长（>9 小时/天）和过短（<6 小时/天）都与大脑体积和认知测量值（记忆力、反应时间、流体智力）降低有关。此外，白天小睡也与大脑体积（灰质和左海马体体积）和认知测量值（反应时间和流体智力）降低有关。中年时期睡眠质量差（<6 小时/天、>9 小时/天、白天小睡）与大脑健康状况较差有关。睡眠可能是改善大脑健康状况、延缓痴呆症发病的一个重要目标。
