Tang Tao, Li Xuewei, Chen Sitong, Xu Qiong, Zhao Heng, Wang Kai, Li Yan, Zhao Mingwei
Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Department of Ophthalmology and Clinical Centre of Optometry, Peking University People's Hospital, Beijing, China.
Eye Vis (Lond). 2023 Feb 2;10(1):6. doi: 10.1186/s40662-022-00324-z.
To investigate ocular biological characteristics for myopic children with axial length (AL) reduction during orthokeratology (Ortho-K) treatment and provide clinical clues for better myopia control effects.
Changes in ocular parameters and treatment zone (TZ) in 75 subjects who completed one-year Ortho-K treatment were retrospectively reviewed. The subjects were divided into two groups according to one-year AL change: the AL reduction group (n = 37) and the AL elongation group (n = 38). Univariate and multivariate regression analyses were performed to determine the association between TZ, ocular parameters, and AL change.
There was no significant difference in baseline between the two groups (all P > 0.05). After one year of Ortho-K treatment, compared with those in the AL elongation group, children in the AL reduction group had a decreased anterior chamber depth (ACD) (P < 0.001), thickened crystalline lens thickness (CLT) (P = 0.002), thinned vitreous chamber depth (VCD) (P < 0.001) and smaller TZ (P = 0.03), but no difference in central corneal thickness (CCT) and pupil diameter (PD). In the multivariable analyses, AL reduction was negatively associated with baseline age (beta: - 0.048; 95% CI: - 0.083 to - 0.013; P = 0.009) and positively associated with the TZ (beta: 0.024; 95% CI: 0.009 to 0.040; P = 0.003).
In AL reduction eyes, thickened CLT, decreased ACD and thinned VCD were observed during Ortho-K treatment, which could be suggested as indicators for better myopia control effects in the clinic. Older baseline age and smaller TZ wearing Ortho-K were also associated with AL change. Thickened CLT may be a result of compensation for AL-reduction eyes.
研究角膜塑形术（Ortho-K）治疗期间眼轴长度（AL）缩短的近视儿童的眼部生物学特征，为更好地控制近视效果提供临床线索。
回顾性分析75例完成一年角膜塑形术治疗的受试者的眼部参数及治疗区（TZ）变化。根据一年的眼轴变化将受试者分为两组：眼轴缩短组（n = 37）和眼轴延长组（n = 38）。进行单因素和多因素回归分析，以确定治疗区、眼部参数与眼轴变化之间的关联。
两组基线无显著差异（所有P>0.05）。角膜塑形术治疗一年后，与眼轴延长组相比，眼轴缩短组儿童的前房深度（ACD）降低（P<0.001），晶状体厚度（CLT）增厚（P = 0.002），玻璃体腔深度（VCD）变薄（P<0.001），治疗区（TZ）较小（P = 0.03），但中央角膜厚度（CCT）和瞳孔直径（PD）无差异。在多变量分析中，眼轴缩短与基线年龄呈负相关（β：-0.048；95%CI：-0.083至-0.013；P = 0.009），与治疗区呈正相关（β：0.024；95%CI：0.009至0.040；P = 0.003）。
在眼轴缩短的眼睛中，角膜塑形术治疗期间观察到晶状体厚度增厚、前房深度降低和玻璃体腔深度变薄，这在临床上可作为更好地控制近视效果的指标。基线年龄较大和角膜塑形术治疗区较小也与眼轴变化有关。晶状体厚度增厚可能是眼轴缩短眼睛的一种代偿结果。
