Carter Alyssa M, Viloria Winnett Alexander, Romano Anna E, Akana Reid, Shelby Natasha, Ismagilov Rustem F
Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
Open Forum Infect Dis. 2023 Jan 5;10(1):ofac701. doi: 10.1093/ofid/ofac701. eCollection 2023 Jan.
During a household-transmission field study using COVID-19 antigen rapid diagnostic tests (Ag-RDT), a common test strip lot was identified among 3 participants with false-positive results. In blinded laboratory evaluation, this lot exhibited a significantly higher false-positive rate than other lots. Because a positive Ag-RDT result often prompts action, reducing lot-specific false positives can maintain confidence and actionability of true-positive Ag-RDT results.
在一项使用新冠病毒抗原快速诊断检测（Ag-RDT）的家庭传播现场研究中，在3名结果为假阳性的参与者中发现了一个常见的试纸批次。在盲法实验室评估中，该批次的假阳性率明显高于其他批次。由于Ag-RDT检测结果呈阳性通常会促使采取行动，减少特定批次的假阳性可以维持对Ag-RDT真阳性结果的信心和可操作性。
