Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China.
Department of Epidemiology and Statistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Front Cell Infect Microbiol. 2023 Jan 16;12:1057298. doi: 10.3389/fcimb.2022.1057298. eCollection 2022.
There is a debate regarding the sensitivity of the QuantiFERON-TB Gold In-Tube (QFT) among people with diabetes, and prior studies have shown heterogeneous results. We evaluated whether the QFT TB antigen was modified among persons with differing diabetes status and other related risk factors.
A cross-sectional study of 5,302 people was conducted to screen latent tuberculosis infection (LTBI) in eastern China. The QFT assay was performed as an indicator of LTBI. Fasting plasma glucose (FPG) was collected from each participant; the definition of diabetes followed the guidelines from the American Diabetes Association. Participants were classified into normoglycemia, prediabetes, undiagnosed diabetes, and previously diagnosed diabetes to evaluate the relationship between the QFT TB antigen and distinct diabetes status.
TB antigen values from the QFT were statistically different among participants with differing diabetes status ( = 0.008). Persons with undiagnosed diabetes had a higher TB antigen value (0.96 ± 0.20) than persons with normoglycemia (0.50 ± 0.02, < 0.05). However, the TB antigen values demonstrated no significant difference among the four different diabetic groups when stratified by the standard cutoff for the QFT ( = 0.492 for the positive group and = 0.368 for the negative group). In a linear regression model, we found that FPG, age, and smoking were positively associated with the QFT TB antigen value ( = 0.017, < 0.001, and < 0.001).
Diabetes status had little influence on the level of QFT TB antigen response among IGRA-positive persons. However, FPG, old age, and smoking were important risk factors for increasing levels of QFT TB antigen.
关于糖尿病患者中 Quantiferon-TB Gold In-Tube（QFT）的敏感性存在争议，先前的研究结果存在差异。我们评估了不同糖尿病状态和其他相关危险因素人群中 QFT 结核抗原是否发生改变。
在中国东部进行了一项横断面研究，共 5302 人参与筛查潜伏性结核感染（LTBI）。QFT 检测作为 LTBI 的指标。每位参与者采集空腹血糖（FPG）；糖尿病的定义遵循美国糖尿病协会的指南。参与者被分为血糖正常、糖尿病前期、未确诊糖尿病和已确诊糖尿病，以评估 QFT 结核抗原与不同糖尿病状态之间的关系。
不同糖尿病状态的参与者中 QFT 的结核抗原值存在统计学差异（ = 0.008）。未确诊糖尿病者的结核抗原值（0.96 ± 0.20）高于血糖正常者（0.50 ± 0.02， < 0.05）。然而，当按 QFT 的阳性标准对四个不同糖尿病组进行分层时，结核抗原值无显著差异（阳性组 = 0.492，阴性组 = 0.368）。在线性回归模型中，我们发现 FPG、年龄和吸烟与 QFT 结核抗原值呈正相关（ = 0.017， < 0.001 和 < 0.001）。
糖尿病状态对 IGRA 阳性者 QFT 结核抗原反应水平的影响较小。然而，FPG、年龄和吸烟是增加 QFT 结核抗原水平的重要危险因素。
