DNA聚合酶I缺陷型大肠杆菌在检测诱变剂和致癌物方面敏感性的提高。
Improvement in the sensitivity of DNA polymerase I-deficient Escherichia coli for detecting mutagens and carcinogens.
作者信息
Venturini S, Monti-Bragadin C
出版信息
Appl Environ Microbiol. 1978 Dec;36(6):794-7. doi: 10.1128/aem.36.6.794-797.1978.
Abstract
The sensitivity of a polA strain to the antibacterial activity of mutagens and carcinogens may be increased by inserting one or both of the following characteristics, a lexA mutation or the R391 bacterial plasmid. The effects of the lexA mutation and the plasmid appear to be additive. The differential sensitivity of a polA lexA (R391) strain could be adapted as a preliminary screening test for mutagens and potential carcinogens.
摘要
通过插入以下一种或两种特性，即lexA突变或R391细菌质粒，polA菌株对诱变剂和致癌物抗菌活性的敏感性可能会增加。lexA突变和质粒的作用似乎是累加的。polA lexA（R391）菌株的差异敏感性可作为诱变剂和潜在致癌物的初步筛选试验。
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