• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection.

作者信息

Feng Fei, Zhu Yunkai, Ma Yanlong, Wang Yuyan, Yu Yin, Sun Xinran, Song Yuanlin, Shao Zhugui, Huang Xinxin, Liao Ying, Ma Jingyun, He Yuping, Wang Mingyuan, Tang Longhai, Huang Yaowei, Zhao Jincun, Ding Qiang, Xie Youhua, Cai Qiliang, Xiao Hui, Li Chun, Yuan Zhenghong, Zhang Rong

机构信息

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.

Department of Pulmonary Medicine, Zhongshan Hospital, Shanghai Key Laboratory of Lung Inflammation and Injury, Fudan University, Shanghai 200032, China.

出版信息

Protein Cell. 2022 Aug 23;14(1):64-68. doi: 10.1093/procel/pwac036. eCollection 2023 Jan.

DOI:10.1093/procel/pwac036
PMID:36726758
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9871949/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adf2/9871949/e64237170786/pwac036_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adf2/9871949/49ae50bb67ef/pwac036_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adf2/9871949/e64237170786/pwac036_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adf2/9871949/49ae50bb67ef/pwac036_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adf2/9871949/e64237170786/pwac036_fig2.jpg

相似文献

1
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection.一项CRISPR激活筛选鉴定出增强新型冠状病毒感染的基因。
Protein Cell. 2022 Aug 23;14(1):64-68. doi: 10.1093/procel/pwac036. eCollection 2023 Jan.
2
Development and application of sensitive, specific, and rapid CRISPR-Cas13-based diagnosis.基于 CRISPR-Cas13 的敏感、特异、快速诊断方法的开发与应用。
J Med Virol. 2021 Jul;93(7):4198-4204. doi: 10.1002/jmv.26889. Epub 2021 Mar 25.
3
Detection of SARS-CoV-2 and Its Mutated Variants via CRISPR-Cas13-Based Transcription Amplification.基于 CRISPR-Cas13 的转录扩增技术检测 SARS-CoV-2 及其突变株。
Anal Chem. 2021 Feb 23;93(7):3393-3402. doi: 10.1021/acs.analchem.0c04303. Epub 2021 Jan 29.
4
Manipulation of genes could inhibit SARS-CoV-2 infection that causes COVID-19 pandemics.基因操纵可以抑制导致 COVID-19 大流行的 SARS-CoV-2 感染。
Exp Biol Med (Maywood). 2021 Jul;246(14):1643-1649. doi: 10.1177/15353702211008106. Epub 2021 Apr 25.
5
Multiplex gRNAs Synergically Enhance Detection of SARS-CoV-2 by CRISPR-Cas12a.多重 gRNA 协同增强 CRISPR-Cas12a 检测 SARS-CoV-2。
CRISPR J. 2023 Apr;6(2):116-126. doi: 10.1089/crispr.2022.0074. Epub 2023 Mar 21.
6
A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.全基因组 CRISPR 敲除筛选发现 PLCSR1 是新冠病毒进入细胞的内在屏障，近期的病毒变异体已进化出抵抗该屏障的能力。
PLoS Biol. 2024 Sep 24;22(9):e3002767. doi: 10.1371/journal.pbio.3002767. eCollection 2024 Sep.
7
Comparative performance of CRISPR-Cas12a assays for SARS-CoV-2 detection tested with RNA extracted from clinical specimens.基于临床标本提取 RNA 检测的用于 SARS-CoV-2 检测的 CRISPR-Cas12a 分析方法的比较性能。
J Virol Methods. 2021 Apr;290:114092. doi: 10.1016/j.jviromet.2021.114092. Epub 2021 Feb 1.
8
Open Sharing During COVID-19: CRISPR-Based Detection Tools.新冠疫情期间的开放共享：基于CRISPR的检测工具
CRISPR J. 2020 Jun;3(3):142-145. doi: 10.1089/crispr.2020.0030.
9
Fast and sensitive CRISPR detection by minimized interference of target amplification.通过最小化目标扩增干扰实现快速灵敏的CRISPR检测。
Nat Chem Biol. 2024 Jul;20(7):885-893. doi: 10.1038/s41589-023-01534-9. Epub 2024 Feb 8.
10
CRISPR is a useful biological tool for detecting nucleic acid of SARS-CoV-2 in human clinical samples.CRISPR是一种用于检测人类临床样本中SARS-CoV-2核酸的有用生物工具。
Biomed Pharmacother. 2021 Aug;140:111772. doi: 10.1016/j.biopha.2021.111772. Epub 2021 May 27.

引用本文的文献

1
Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E.糖基磷脂酰肌醇生物合成通过对LY6E的调控，作为一种针对冠状病毒的保守宿主防御途径发挥作用。
PLoS Pathog. 2025 Sep 3;21(9):e1013441. doi: 10.1371/journal.ppat.1013441. eCollection 2025 Sep.
2
Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism.全膜筛选确定了新冠病毒嗜性的潜在组织特异性决定因素。
PLoS Pathog. 2025 Jul 17;21(7):e1013157. doi: 10.1371/journal.ppat.1013157. eCollection 2025 Jul.

本文引用的文献

1
DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist.DC/L-SIGN对刺突糖蛋白的识别促进了SARS-CoV-2的转染，并且可以被一种糖模拟拮抗剂所抑制。
PLoS Pathog. 2021 May 20;17(5):e1009576. doi: 10.1371/journal.ppat.1009576. eCollection 2021 May.
2
A novel cell culture system modeling the SARS-CoV-2 life cycle.一种新型的细胞培养系统，可模拟 SARS-CoV-2 的生命周期。
PLoS Pathog. 2021 Mar 12;17(3):e1009439. doi: 10.1371/journal.ppat.1009439. eCollection 2021 Mar.
3
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.
整合素结合肽ATN-161作为治疗新型冠状病毒肺炎的新疗法
JACC Basic Transl Sci. 2021 Jan;6(1):1-8. doi: 10.1016/j.jacbts.2020.10.003. Epub 2020 Oct 16.
4
Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium.新冠病毒在重塑的人类心室心肌中结合及细胞进入机制的动态调控
JACC Basic Transl Sci. 2020 Sep;5(9):871-883. doi: 10.1016/j.jacbts.2020.06.007. Epub 2020 Jun 24.
5
A potential role for integrins in host cell entry by SARS-CoV-2.整合素在 SARS-CoV-2 进入宿主细胞中的潜在作用。
Antiviral Res. 2020 May;177:104759. doi: 10.1016/j.antiviral.2020.104759. Epub 2020 Mar 1.
6
Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry.抗 Siglec-1 抗体可阻断埃博拉病毒的摄取并减少细胞质内的病毒进入。
Nat Microbiol. 2019 Sep;4(9):1558-1570. doi: 10.1038/s41564-019-0453-2. Epub 2019 Jun 3.
7
Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner.小鼠唾液酸结合免疫球蛋白样凝集素-1以唾液酸N-酰基侧链依赖性方式介导表面结合的鼠白血病病毒的转感染。
J Biol Chem. 2015 Nov 6;290(45):27345-27359. doi: 10.1074/jbc.M115.681338. Epub 2015 Sep 14.
8
Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice.流式细胞术揭示人类和小鼠肺巨噬细胞之间的相似性。
Am J Respir Cell Mol Biol. 2016 Jan;54(1):147-9. doi: 10.1165/rcmb.2015-0147LE.
9
Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues.人血液、支气管肺泡灌洗液和肺组织中髓样细胞的流式细胞术分析
Am J Respir Cell Mol Biol. 2016 Jan;54(1):13-24. doi: 10.1165/rcmb.2015-0146OC.
10
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.通过工程化的CRISPR-Cas9复合物进行全基因组规模的转录激活
Nature. 2015 Jan 29;517(7536):583-8. doi: 10.1038/nature14136. Epub 2014 Dec 10.