Li Yuan, Zhen Xiaole, Yao Xiaojuan, Lu Jiejie
Dermatology Department, the Fifth People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jan 26;16:253-256. doi: 10.2147/CCID.S394754. eCollection 2023.
Minocycline is a tetracycline derivative antibiotic commonly used to treat acne, rosacea, and other inflammatory skin conditions. Taking minocycline risks inducing skin pigmentation. If minocycline-induced hyperpigmentation is not treated, it may take months to years for the symptoms to subside after discontinuation of the drug, or the hyperpigmentation may never disappear completely, which can lead to cosmetic anxiety and affect people's quality of life. Previous treatment options for hyperpigmentation were mainly q-switched nd: YAG, ruby, and alexandrite lasers. This article reports a case of facial hyperpigmentation caused by minocycline using a combination of chemical peel and intense pulsed light in a patient with eosinophilic cellulitis (Wells syndrome) who was taking oral minocycline. This case suggests combining chemical peel and intense pulsed light is an effective treatment option for minocycline-induced hyperpigmentation.
米诺环素是一种四环素类衍生物抗生素，常用于治疗痤疮、酒渣鼻和其他炎症性皮肤病。服用米诺环素存在诱发皮肤色素沉着的风险。如果不治疗米诺环素引起的色素沉着，停药后症状可能需要数月至数年才能消退，或者色素沉着可能永远不会完全消失，这会导致美容焦虑并影响人们的生活质量。以前针对色素沉着的治疗方法主要是调Q Nd:YAG激光、红宝石激光和翠绿宝石激光。本文报告了一例正在口服米诺环素的嗜酸性蜂窝织炎（韦尔斯综合征）患者，使用化学剥脱术和强脉冲光联合治疗米诺环素引起的面部色素沉着的病例。该病例表明，化学剥脱术和强脉冲光联合治疗是米诺环素引起的色素沉着的一种有效治疗选择。
