Cao Yue, Xu Peng, Shen Yangling, Wu Wei, Chen Min, Wang Fei, Zhu Yuandong, Yan Feng, Gu Weiying, Lin Yan
Department of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Department of Hematology, Soochow Hopes Hematology Hospital, Suzhou, Jiangsu, China.
Front Oncol. 2023 Jan 16;12:1118101. doi: 10.3389/fonc.2022.1118101. eCollection 2022.
As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progression. Cancer cells and the immune microenvironment interact and restrict each other. Tumor-derived exosomes (TDEs) have become essential players in this balance because they carry information from the original cancer cells and express complexes of MHC class I/II epitopes and costimulatory molecules. In the present study, we aimed to identify potential targets for exosome therapy by examining the specific expression and mechanism of exosomes derived from cancer cells. We introduced TDEs and explored their role in different tumor immune microenvironment (TIME), with a particular emphasis on gastrointestinal cancers, before briefly describing the therapeutic strategies of exosomes in cancer immune-related therapy.
作为各种细胞分泌的磷脂细胞外囊泡（EVs），外泌体包含非编码RNA（ncRNA）、mRNA、DNA片段、脂质和蛋白质，这些对于细胞间通讯至关重要。几种类型的细胞可以分泌有助于癌症起始和进展的外泌体。癌细胞与免疫微环境相互作用并相互制约。肿瘤来源的外泌体（TDEs）已成为这种平衡中的关键参与者，因为它们携带来自原始癌细胞的信息，并表达MHC I/II类表位和共刺激分子复合物。在本研究中，我们旨在通过检查癌细胞来源外泌体的特异性表达和机制来确定外泌体治疗的潜在靶点。我们引入了TDEs并探讨了它们在不同肿瘤免疫微环境（TIME）中的作用，特别关注胃肠道癌症，然后简要描述了外泌体在癌症免疫相关治疗中的治疗策略。
