Noda Tomomi, Isobe Masanori, Mishima Ryo, Tose Keima, Kawabata Michiko, Aso Toshihiko, Tei Shisei, Noma Shun'ichi, Murai Toshiya
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan.
Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Japan.
BJPsych Open. 2023 Feb 2;9(1):e22. doi: 10.1192/bjo.2022.637.
We examined the neural underpinnings of the effects of mindfulness on anxiety in anorexia nervosa using functional magnetic resonance imaging in 21 anorexia patients. We used a functional magnetic resonance imaging task designed to induce weight-related anxiety and asked participants to regulate their anxiety either using or not using an acceptance strategy. Our results showed reduced activity in the amygdala, anterior cingulate cortex, putamen, caudate, orbital gyrus, middle frontal gyrus, posterior cingulate cortex and precuneus following a mindfulness-based intervention. The present study provides new insight regarding the neural mechanisms underlying the effect of mindfulness-based intervention in ameliorating anorexia nervosa.
我们使用功能磁共振成像技术，对21名神经性厌食症患者进行研究，以探究正念对神经性厌食症焦虑影响的神经基础。我们采用了一项旨在诱发与体重相关焦虑的功能磁共振成像任务，并要求参与者使用或不使用接纳策略来调节自身焦虑。我们的研究结果显示，基于正念的干预后，杏仁核、前扣带回皮质、壳核、尾状核、眶回、额中回、后扣带回皮质和楔前叶的活动减少。本研究为基于正念的干预改善神经性厌食症的神经机制提供了新的见解。
