Institut des Sciences et Ingénierie Chimiques École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Department of Chemistry, University of Rome Tor Vergata Via della Ricerca Scientifica, 00133 Rome, Italy.
Chem Commun (Camb). 2023 Feb 16;59(15):2146-2149. doi: 10.1039/d2cc06525h.
Control over synthetic DNA-based nanodevices can be achieved with a variety of physical and chemical stimuli. Actuation with light, however, is as advantageous as difficult to implement without modifying DNA strands with photo-switchable groups. Herein, we show that DNA nanodevices can be controlled using visible light in photo-switchable aqueous buffer solutions in a reversible and highly programmable fashion. The strategy presented here is non-invasive and allows the remote control with visible light of complex operations of DNA-based nanodevices such as the reversible release/loading of cargo molecules.
可以通过各种物理和化学刺激来控制基于合成 DNA 的纳米器件。然而，在不通过光致变色基团修饰 DNA 链的情况下，用光来驱动是有利的，但很难实现。在这里，我们展示了 DNA 纳米器件可以在光致变色的水溶液缓冲溶液中使用可见光以可逆和高度可编程的方式进行控制。这里提出的策略是非侵入性的，可以使用可见光远程控制基于 DNA 的纳米器件的复杂操作，例如货物分子的可逆释放/加载。
