Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
J Endocrinol. 2023 Mar 16;257(1). doi: 10.1530/JOE-22-0278. Print 2023 Apr 1.
Glucagon is secreted by the pancreatic alpha cell and has long been known to oppose insulin action. A lyophilized form of the hormone has been available to treat episodes of insulin-induced hypoglycemia in insulin-treated people with diabetes for decades, but the difficulty of use was a barrier to widespread utilization. Newer formulations of glucagon are stable at room temperature in single-use devices that many caregivers find are easier to use than the original glucagon emergency kit. In this review , we will review what is known about the role of glucagon in normal physiology and diabetes and then discuss how the research in this area has been translated into treatment for metabolic conditions.
胰高血糖素由胰岛α细胞分泌，长期以来一直被认为与胰岛素作用相反。该激素的冻干形式已被用于治疗数十年的糖尿病患者因胰岛素引起的低血糖发作，但由于使用困难，限制了其广泛应用。新型的胰高血糖素制剂在室温下稳定，可在单次使用的设备中使用，许多护理人员发现这种设备比原来的胰高血糖素急救包更容易使用。在这篇综述中，我们将回顾胰高血糖素在正常生理和糖尿病中的作用，然后讨论该领域的研究如何转化为代谢疾病的治疗方法。
