眼前节光学相干断层扫描血管造影在评估眼部红肿中的新应用。

Novel Application of Conjunctival Anterior Segment Optical Coherence Tomography Angiography to Assess Ocular Redness.

机构信息

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA; and.

Cornea Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA.

出版信息

Cornea. 2023 Dec 1;42(12):1520-1527. doi: 10.1097/ICO.0000000000003239. Epub 2023 Jan 20.

DOI:10.1097/ICO.0000000000003239

PMID:36727742

Abstract

PURPOSE

The aim of this study was to determine anterior segment optical coherence tomography angiography (AS-OCTA) parameters to assess ocular redness severity.

METHODS

AS-OCTA analyses of 60 eyes of 40 patients were grouped according to ocular redness stages using the 5-category validated bulbar redness scale in a cross-sectional retrospective study (groups 1-5). A subset of patients with slit-lamp photographs, total 35 eyes of 23 patients, were assessed with 10-category validated bulbar redness scale for comparison. AS-OCTA images of nasal and temporal bulbar conjunctiva were analyzed. Vessel density (VD) represented the blood flow pixels by the total pixels of image (%); vessel diameter index represented the VD by the skeletonized density; fractal dimension, measured with the box-count method, represented the vessel branching complexity. Averaged nasal and temporal parameters for each eye were correlated to validated bulbar redness scales.

RESULTS

There was no statistical difference between groups for age ( P = 0.118), sex ( P = 0.501), eye laterality (OD/OS; P = 0.111), or location (nasal/temporal; P = 0.932). In the 5-category scale, VD significantly increased from group 1 to 2 (31.5 ± 1.9% and 33.4 ± 2.2%, P = 0.023), 2 to 3 (36.0 ± 3.5%, P < 0.001), and 4 to 5 (40.2 ± 2.9 and 46.5 ± 2.8, P < 0.001). The correlations were 0.805 ( P < 0.001) and 0.893 ( P < 0.001) for the 5-category and 10-category scales, respectively. Vessel diameter index showed a significant increase from 1 to 2 (2.90 ± 0.17 and 3.00 ± 0.15; P = 0.004) and 4 to 5 (2.92 ± 0.31 and 3.33 ± 0.08; P = 0.001). The correlations were 0.550 ( P < 0.001) and 0.625 ( P < 0.001) for the respective scales. The fractal dimension showed no significant differences between subsequent groups. The correlations were 0.445 ( P < 0.001) and 0.583 ( P < 0.001), respectively.

CONCLUSIONS

Conjunctival AS-OCTA VD was the most reliable parameter to assess ocular redness.

摘要

目的

本研究旨在确定眼前节光学相干断层扫描血管造影（AS-OCTA）参数，以评估眼部红肿的严重程度。

方法

在一项横断面回顾性研究中，根据 5 级验证的球结膜红肿量表（1-5 组），将 40 例患者的 60 只眼的 AS-OCTA 分析分组。共有 23 例患者的 35 只眼有裂隙灯照片，用 10 级验证的球结膜红肿量表进行评估作为比较。分析鼻侧和颞侧球结膜的 AS-OCTA 图像。血管密度（VD）代表图像中血流像素的总像素（%）；血管直径指数代表骨架密度的 VD；分形维数通过盒子计数法测量，代表血管分支的复杂性。每只眼的平均鼻侧和颞侧参数与验证的球结膜红肿量表相关。

结果

各组之间的年龄（P=0.118）、性别（P=0.501）、眼侧（OD/OS；P=0.111）或位置（鼻侧/颞侧；P=0.932）无统计学差异。在 5 级量表中，从第 1 组到第 2 组（31.5±1.9%和 33.4±2.2%，P=0.023）、第 2 组到第 3 组（36.0±3.5%，P<0.001）、第 4 组到第 5 组（40.2±2.9%和 46.5±2.8%，P<0.001）VD 显著增加。相关性分别为 0.805（P<0.001）和 0.893（P<0.001）。血管直径指数从第 1 组到第 2 组（2.90±0.17 和 3.00±0.15；P=0.004）和第 4 组到第 5 组（2.92±0.31 和 3.33±0.08；P=0.001）均显著增加。相关性分别为 0.550（P<0.001）和 0.625（P<0.001）。分形维数在随后的各组之间没有显著差异。相关性分别为 0.445（P<0.001）和 0.583（P<0.001）。