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成骨不全患者的牙种植体——6例患者的临床和影像学结果

Dental Implants in Patients with Osteogenesis Imperfecta - Clinical and Radiographic Outcome in Six Patients.

作者信息

Fogh Frederikke Maria, Jensen Simon Storgård, Kofod Thomas, Lauridsen Eva

出版信息

Oral Health Prev Dent. 2023 Feb 2;21:33-40. doi: 10.3290/j.ohpd.b3858615.

DOI:10.3290/j.ohpd.b3858615
PMID:36727836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11619852/
Abstract

PURPOSE

To investigate the survival rate of dental implants in patients diagnosed with osteogenesis imperfecta (OI).

MATERIALS AND METHODS

The study is a retrospective analysis of six individuals (2 males, 4 females) with OI (type I, III and IV) with a total of 25 dental implants. Clinical examination included plaque index, gingival index, periodontal pocket depth for each implant, presence of pus, and loosening of the implant(s). Marginal bone loss was measured on radiographs. The observation period ranged from 2-17 years (mean:7.5 years, median: 5 years).

RESULTS

The overall implant survival rate was 80%. One patient with OI type III lost five implants. However, four out of five lost implants functioned for 11 years.

CONCLUSION

Dental implant treatment seems to be a valid option for replacing missing teeth in OI patients. It is recommended that patients diagnosed with OI undergo the same preoperative evaluation as regular dental implant patients with special emphasis on a healthy periodontal status and ideal oral hygiene.

摘要

目的

研究成骨不全症(OI)患者牙种植体的存活率。

材料与方法

本研究对6例(2例男性,4例女性)患有OI(I型、III型和IV型)的患者共25颗牙种植体进行回顾性分析。临床检查包括菌斑指数、牙龈指数、每个种植体的牙周袋深度、有无脓液以及种植体松动情况。通过X线片测量边缘骨吸收。观察期为2至17年(平均:7.5年,中位数:5年)。

结果

种植体总体存活率为80%。1例III型OI患者的5颗种植体脱落。然而,5颗脱落种植体中有4颗发挥功能达11年。

结论

牙种植治疗似乎是OI患者缺失牙修复的有效选择。建议诊断为OI的患者接受与常规牙种植患者相同的术前评估,特别强调健康的牙周状况和理想的口腔卫生。

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Oral health-related quality of life in X-linked hypophosphataemia and osteogenesis imperfecta.伴 X 连锁低磷血症性佝偻病和成骨不全症的口腔健康相关生活质量。
J Oral Rehabil. 2021 Feb;48(2):160-168. doi: 10.1111/joor.13114. Epub 2020 Nov 19.
2
The dental perspective on osteogenesis imperfecta in a Danish adult population.丹麦成年人群中牙科学对成骨不全症的观点。
BMC Oral Health. 2018 Oct 24;18(1):175. doi: 10.1186/s12903-018-0639-7.
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The effect of antiresorptive drugs on implant therapy: Systematic review and meta-analysis.抗吸收药物对种植体治疗的影响:系统评价和荟萃分析。
Clin Oral Implants Res. 2018 Oct;29 Suppl 18:54-92. doi: 10.1111/clr.13282.
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Implant-supported fixed prostheses in a Patient with Osteogenesis Imperfecta: A 4-year follow-up.成骨不全患者的种植体支持固定义齿:4年随访
J Clin Exp Dent. 2017 Dec 1;9(12):e1482-e1486. doi: 10.4317/jced.53958. eCollection 2017 Dec.
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Tooth agenesis in osteogenesis imperfecta related to mutations in the collagen type I genes.与I型胶原蛋白基因突变相关的成骨不全症中的牙齿发育不全。
Oral Dis. 2017 Jan;23(1):42-49. doi: 10.1111/odi.12568. Epub 2016 Sep 13.
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Skeletal phenotypes in adult patients with osteogenesis imperfecta-correlations with COL1A1/COL1A2 genotype and collagen structure.成骨不全成年患者的骨骼表型——与COL1A1/COL1A2基因型及胶原蛋白结构的相关性
Osteoporos Int. 2016 Nov;27(11):3331-3341. doi: 10.1007/s00198-016-3653-0. Epub 2016 Jun 2.
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Circulation. 2016 Feb 9;133(6):576-83. doi: 10.1161/CIRCULATIONAHA.115.020324. Epub 2016 Jan 13.
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Lancet. 2016 Apr 16;387(10028):1657-71. doi: 10.1016/S0140-6736(15)00728-X. Epub 2015 Nov 3.
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Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials.双膦酸盐预防成骨不全骨折:安慰剂对照试验的荟萃分析
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