前瞻性队列研究中乳糜泻高危儿童的早期抗体动态变化。
Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease.
机构信息
Pediatric Unit, "San Giovanni di Dio e Ruggi d'Aragona" University Hospital, Salerno, Italy.
European Biomedical Research Institute of Salerno, Salerno, Italy.
出版信息
Am J Gastroenterol. 2023 Mar 1;118(3):574-577. doi: 10.14309/ajg.0000000000002192. Epub 2023 Jan 20.
INTRODUCTION
The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.
METHODS
A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).
RESULTS
Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.
DISCUSSION
Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.
简介
本研究旨在确定可能的血清生物标志物，以预测处于风险中的儿童发生乳糜泻（CD）。
方法
对一项正在进行的、针对 CD 高危儿童的国际前瞻性研究的亚组，根据脱酰胺麦胶蛋白肽（DGPs）免疫球蛋白（Ig）G 的早期轨迹和临床结果（CD、潜在 CD 和 CD 自身免疫）进行分类。
结果
325 名儿童中有 38 名出现抗组织转谷氨酰胺酶 IgA 抗体（anti-tTG IgA）血清转化。在首次抗-tTG IgA 血清转化之前，38 名儿童中有 28 名（73.6%）出现抗-DGPs IgG 增加。
讨论
抗-DGPs IgG 可能是预测高危儿童 CD 发病的早期临床前生物标志物。
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