National Centre for Functional Gastrointestinal Disorders, Haukeland University Hospital, Bergen, Norway.
National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
Scand J Gastroenterol. 2023 Jul;58(7):718-725. doi: 10.1080/00365521.2023.2173533. Epub 2023 Feb 2.
Gastrointestinal symptoms are common in ME/CFS, but there is a knowledge gap in the literature concerning gastrointestinal motility features and detailed symptom description.
In this study, we aimed to characterize gastric motility and gastric symptoms in response to a liquid meal.
We included 20 patients with ME/CFS with abdominal complaints who were recruited to a double-blind randomized placebo-controlled trial of Rituximab. The patients of this sub study were examined with an ultrasound drink test, and gastrointestinal symptoms were evaluated using the Rome III questionnaire and Irritable Bowel Syndrome Symptom Severity Scale (IBS-SSS) questionnaire.
We found that patients commonly reported fullness/bloating (75%), abdominal pain (45%) and nausea (35%). Ultrasound measurements revealed lower proximal measurements of the stomach after a meal ( 0.01) and larger fasting antral area ( = 0.019) compared to healthy controls. The patients had a stronger symptomatic response to the liquid meal compared to healthy controls regarding epigastric pain, discomfort and nausea ( 0.05).Ninety percent of the patients reported bowel movement frequencies within the normal range but scored high on bowel habit dissatisfaction and life disruption.
The patients presented with fullness/bloating, nausea and epigastric pain, showed signs of impaired gastric accommodation and visceral hypersensitivity, showing that the gastrointestinal symptoms of ME/CFS patients are similar to functional dyspepsia.Key summary Gastrointestinal symptoms are common in ME/CFS, but there is a knowledge gap in the literature concerning gastrointestinal motility features and detailed symptom description. • In this study, patients with ME/CFS had signs of impaired gastric accommodation after a liquid meal. • Out of 20 patients, 15 patients reported fullness/bloating, 9 reported abdominal pain, and 7 reported nausea. The patients showed signs of visceral hypersensitivity on a drink test. • Our findings suggest that patients with ME/CFS share many similarities with patients with Functional Dyspepsia. The findings were not typical for Irritable Bowel Syndrome.
胃肠道症状在肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）中很常见，但文献中关于胃肠道动力特征和详细症状描述的知识存在差距。
本研究旨在描述液体餐刺激后的胃动力和胃症状。
我们纳入了 20 名有腹部不适的 ME/CFS 患者，这些患者参与了一项利妥昔单抗双盲随机安慰剂对照试验。这项子研究使用超声饮料测试检查了这些患者，并使用罗马 III 问卷和肠易激综合征症状严重程度量表（IBS-SSS）问卷评估胃肠道症状。
我们发现患者常报告饱胀/腹胀（75%）、腹痛（45%）和恶心（35%）。超声测量显示，与健康对照组相比，餐后胃近端的测量值较低（0.01），空腹胃窦面积较大（=0.019）。与健康对照组相比，患者对液体餐的上腹部疼痛、不适和恶心的症状反应更强烈（0.05）。90%的患者报告排便频率在正常范围内，但对排便习惯不满和生活干扰的评分较高。
患者表现出饱胀/腹胀、恶心和上腹痛，提示胃容纳能力受损和内脏高敏，表明 ME/CFS 患者的胃肠道症状与功能性消化不良相似。
胃肠道症状在肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）中很常见，但文献中关于胃肠道动力特征和详细症状描述的知识存在差距。在这项研究中，ME/CFS 患者在饮用液体餐后胃容纳能力受损。20 名患者中，15 名报告有饱胀/腹胀，9 名报告有腹痛，7 名报告有恶心。患者在饮料测试中表现出内脏高敏的迹象。我们的发现表明，ME/CFS 患者与功能性消化不良患者有许多相似之处，而不是典型的肠易激综合征。
