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天然抗菌化合物的纳米脂质体递送系统:性质、应用及最新进展

Nanoliposomal delivery systems of natural antibacterial compounds; properties, applications, and recent advances.

作者信息

Yousefi Mohammad, Andishmand Hashem, Assadpour Elham, Barzegar Ali, Kharazmi Mohammad Saeed, Jafari Seid Mahdi

机构信息

Food and Beverage Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran.

Department of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Crit Rev Food Sci Nutr. 2024;64(19):6498-6511. doi: 10.1080/10408398.2023.2170318. Epub 2023 Feb 2.

DOI:10.1080/10408398.2023.2170318
PMID:36728840
Abstract

Todays, nanoliposomes (NLPs) are considered as one of the most efficient nanocarriers to deal with bacteria, practically in food products. These nanodelivery systems are able to be loaded with different bioactive compounds. The main aim of this review is investigating recent approaches (mostly from the years of 2018 to 2022) regarding development of nanoliposomal natural antibacterial compounds. In this regard, NLPs alone, combined with films, coatings, or fibers, and in coated forms are reviewed as advanced delivery systems of antibacterial substances. Moreover, a robust and comprehensive coverage of the morphological and physical properties of formulated NLPs as well as their interactions with antibacterial substances are discussed. The importance of NLPs to encapsulate antibacterial ingredients, advantages and drawbacks, antibacterial pathways of formulated NLPs, and comparison of them with pure antibacterial bioactive compounds are also explained.

摘要

如今,纳米脂质体(NLPs)被认为是处理细菌最有效的纳米载体之一,实际上在食品中也是如此。这些纳米递送系统能够负载不同的生物活性化合物。本综述的主要目的是研究最近(主要是2018年至2022年)关于纳米脂质体天然抗菌化合物开发的方法。在这方面,单独的纳米脂质体、与薄膜、涂层或纤维结合以及涂层形式的纳米脂质体作为抗菌物质的先进递送系统进行了综述。此外,还讨论了所制备纳米脂质体的形态和物理性质及其与抗菌物质的相互作用,并进行了全面而深入的阐述。还解释了纳米脂质体包封抗菌成分的重要性、优缺点、所制备纳米脂质体的抗菌途径以及它们与纯抗菌生物活性化合物的比较。

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