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基于纳米脂质体的抗菌药物递送。

Nanoliposome-based antibacterial drug delivery.

机构信息

Immunology Research Center & Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran and.

出版信息

Drug Deliv. 2015;22(5):581-9. doi: 10.3109/10717544.2013.863409. Epub 2013 Dec 9.

Abstract

Although most bacterial infectious diseases can be treated successfully with the remarkable array of antibiotics, the microbial pathogens continue to be one of the most critical health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antibacterial delivery systems since inefficient delivery can lead to poor therapeutic outcome of the administered drug. Recently, nanoliposomal systems have been widely used as promising strategies to overcome these challenges due to their unique set of properties. This article tries to briefly summarize the current studies that have taken advantage of liposomal nanoparticles as carriers to deliver antibacterial agents. The reviewed investigations demonstrate the immense potential of liposomal nanoparticles as carriers for antibiotic delivery and highlight the latent promise in this class of vehicles for treatment of bacterial infections. The future of these promising approaches lies in the development of more efficient techniques for preparing liposomal nanoparticles with great potential in effective and selective targeting of antibiotics to bacterial cells for eradication as well as the highest safety for human host.

摘要

尽管大多数细菌性传染病都可以通过一系列出色的抗生素成功治疗,但微生物病原体仍然是全球最严重的健康挑战之一。解决这个问题的常见方法之一是改进现有的抗菌药物输送系统,因为输送效率低下会导致所使用药物的治疗效果不佳。最近,由于其独特的一系列特性,脂质体纳米系统已被广泛用作克服这些挑战的有前途的策略。本文试图简要总结利用脂质体纳米颗粒作为载体来输送抗菌剂的当前研究。综述的研究表明,脂质体纳米颗粒作为载体用于抗生素输送具有巨大的潜力,并突出了这类载体在治疗细菌感染方面的潜在前景。这些有前途的方法的未来在于开发更有效的技术来制备脂质体纳米颗粒,以有效地将抗生素靶向细菌细胞进行清除,并为人体宿主提供最高的安全性。

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