Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, P. R. China.
Marine Biomedical Research Institute, the Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, 524023, P. R. China.
Chem Biodivers. 2023 Mar;20(3):e202300082. doi: 10.1002/cbdv.202300082. Epub 2023 Feb 15.
Five new C -steroidal sapogenins (1-5) named cynotogenins J-N, were isolated from the acid hydrolysate of Cynanchum otophyllum roots. Their structures were established by extensive spectroscopic analysis (UV, IR, HR-ESI-MS, and NMR). Most notably, compounds 1-3 harboring a rare 5β,6β-epoxy group in the C -steroidal skeleton of Cynanchum plants. All compounds were evaluated for their cytotoxicities against multiple cancer cell lines, in which compounds 5 showed weak cytotoxicity against HepG2 cancer cells with IC values of 44.90 μM.
从鹅绒藤根的酸水解产物中分离得到了五个新的 C-甾体皂甙元（1-5），命名为 Cynotogenins J-N。通过广泛的光谱分析（UV、IR、HR-ESI-MS 和 NMR）确定了它们的结构。值得注意的是，化合物 1-3 含有在 Cynanchum 植物的 C-甾体骨架中罕见的 5β,6β-环氧基。所有化合物都评估了对多种癌细胞系的细胞毒性，其中化合物 5 对 HepG2 癌细胞表现出较弱的细胞毒性，IC 值为 44.90 μM。
