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阻止脂肪生成：重新利用一种抗抑郁药治疗癌症。

Stopping the fat: Repurposing an antidepressant for cancer treatment.

机构信息

Cell and Molecular Biology of Cancer Program, National Cancer Institute Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA, USA.

出版信息

J Exp Med. 2023 Mar 6;220(3). doi: 10.1084/jem.20222097. Epub 2023 Feb 2.

DOI:10.1084/jem.20222097
PMID:36729077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9929654/
Abstract

In this issue of JEM, Chu and An et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression.

摘要

在本期《实验医学杂志》中，Chu 和 An 等人（2022. J. Exp. Med.https://doi.org/10.1084/jem.20221316）描述了三环类抗抑郁药去甲替林在抑制脂肪酸摄取中的作用。去甲替林促进细胞酸化并抑制巨胞饮作用，为脂肪酸摄取与肿瘤进展之间提供了联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7e/9929654/99e7a139eea1/JEM_20222097_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7e/9929654/f4411396ccf6/JEM_20222097_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7e/9929654/99e7a139eea1/JEM_20222097_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7e/9929654/f4411396ccf6/JEM_20222097_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7e/9929654/99e7a139eea1/JEM_20222097_Fig2.jpg

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本文引用的文献

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Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways.巨胞饮作用与癌症：从肿瘤应激到信号通路。
Subcell Biochem. 2022;98:15-40. doi: 10.1007/978-3-030-94004-1_2.
2
Tumour fatty acid metabolism in the context of therapy resistance and obesity.治疗抵抗和肥胖背景下的肿瘤脂肪酸代谢
Nat Rev Cancer. 2021 Dec;21(12):753-766. doi: 10.1038/s41568-021-00388-4. Epub 2021 Aug 20.
3
The Golgi as a "Proton Sink" in Cancer.高尔基体作为癌症中的“质子汇”
Nebivolol, an antihypertensive agent, has new application in inhibiting melanoma.
奈必洛尔，一种降压药，在抑制黑色素瘤方面有新的应用。
Anticancer Drugs. 2024 Jul 1;35(6):512-524. doi: 10.1097/CAD.0000000000001597. Epub 2024 Apr 11.
Front Cell Dev Biol. 2021 May 13;9:664295. doi: 10.3389/fcell.2021.664295. eCollection 2021.
4
Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells.NHE7 通过调节胰腺癌细胞中的细胞溶质 pH 稳态来进行高尔基体酸化。
Cancer Discov. 2020 Jun;10(6):822-835. doi: 10.1158/2159-8290.CD-19-1007. Epub 2020 Mar 21.
5
Macropinocytosis in Cancer: A Complex Signaling Network.癌症中的巨胞饮作用：一个复杂的信号网络
Trends Cancer. 2019 Jun;5(6):332-334. doi: 10.1016/j.trecan.2019.04.002. Epub 2019 May 9.
6
Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer.巨吞饮作用：癌症中对营养应激的一种代谢适应
Front Endocrinol (Lausanne). 2017 Sep 29;8:261. doi: 10.3389/fendo.2017.00261. eCollection 2017.
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