阻止脂肪生成：重新利用一种抗抑郁药治疗癌症。
Stopping the fat: Repurposing an antidepressant for cancer treatment.
机构信息
Cell and Molecular Biology of Cancer Program, National Cancer Institute Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA, USA.
出版信息
J Exp Med. 2023 Mar 6;220(3). doi: 10.1084/jem.20222097. Epub 2023 Feb 2.
Abstract
In this issue of JEM, Chu and An et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression.
摘要
在本期《实验医学杂志》中，Chu 和 An 等人（2022. J. Exp. Med.https://doi.org/10.1084/jem.20221316）描述了三环类抗抑郁药去甲替林在抑制脂肪酸摄取中的作用。去甲替林促进细胞酸化并抑制巨胞饮作用，为脂肪酸摄取与肿瘤进展之间提供了联系。
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