Pierre Fabre Dermo-Cosmétique and, Personal Care, Toulouse, France.
Direction Médicale DUCRAY, Lavaur, France.
J Eur Acad Dermatol Venereol. 2023 Mar;37 Suppl 2:20-25. doi: 10.1111/jdv.18792.
Acne is a multifactorial chronic inflammatory disease of the pilosebaceous unit, where Cutibacterium acnes plays a main role. Recent papers demonstrated that specific C. acnes phylotypes were correlated with the severity of inflammatory acne and reported a specific loss of C. acnes phylotype diversity in this context.
The aim of this exploratory study was to evaluate the efficacy of a new dermocosmetic product containing Myrtus communis and Celastrol-enriched plant cell culture extracts on C. acnes phylotype abundance and clinical parameters in subjects with mild to moderate acne vulgaris.
Cutibacterium acnes phylotype diversity was evaluated by single-locus sequence typing sequencing on the nonlesional areas of the forehead, that is, areas excluding inflammatory lesions (papules and pustules) on day 1 (D1) and after 56 days (D57) of twice daily application of the dermocosmetic product on the whole face. Clinical efficacy on acne was also assessed by acne lesion counting and Global Evaluation Acne (GEA) score on D1 and D57.
Our study confirmed the link between the presence of some C. acnes phylotypes and acne severity. The dermocosmetic cream was linked to a positive impact on C. acnes phylotypes: a significant decrease in pro-pathogen phylotype IC and increase in nonpathogen phylotype IB were observed in the nonlesional areas of acne on D57 compared to D1. In parallel, the clinical results showed a significant decrease in inflammatory and comedonal acne lesions and a significant improvement in the acne severity according to the GEA score.
This study showed that the application of a new dermocosmetic product containing M. communis and Celastrol-enriched plant cell culture extracts was linked to a change in the C. acnes phylotype abundance and an improvement in acne severity.
痤疮是一种多因素的、累及皮脂腺的慢性炎症性疾病，其中痤疮丙酸杆菌起着主要作用。最近的研究表明，特定的痤疮丙酸杆菌菌群与炎症性痤疮的严重程度相关，并报告了在这种情况下，痤疮丙酸杆菌菌群多样性的特异性丧失。
本探索性研究旨在评估一种含有桃金娘醇和富含 Celastrol 的植物细胞培养提取物的新型皮肤护理产品对轻中度寻常痤疮患者痤疮丙酸杆菌菌群丰度和临床参数的疗效。
采用单基因序列分型测序技术，在额头非皮损区（即不包括炎性皮损[丘疹和脓疱]的区域）评估痤疮丙酸杆菌菌群多样性，分别在基线（D1）和每天两次应用皮肤护理产品 56 天后（D57）评估。在 D1 和 D57 时，还通过痤疮皮损计数和全球痤疮评估（GGE）评分评估痤疮的临床疗效。
本研究证实了某些痤疮丙酸杆菌菌群与痤疮严重程度之间的关联。皮肤护理霜与痤疮丙酸杆菌菌群的积极影响有关：与 D1 相比，在痤疮的非皮损区，D57 时促病病原体菌群 IC 显著减少，非病原体菌群 IB 显著增加。与此同时，临床结果显示，炎性和粉刺性痤疮皮损数量显著减少，根据 GGE 评分，痤疮严重程度显著改善。
本研究表明，应用一种含有桃金娘醇和富含 Celastrol 的植物细胞培养提取物的新型皮肤护理产品与痤疮丙酸杆菌菌群丰度的变化和痤疮严重程度的改善有关。
