Schwarzstein L, Aparicio N J, Turner D, de Turner E A, Premoli F, Rodriguez A, Schally A V
Int J Fertil. 1976(2):96-102.
A comparative study was done of the basal and post-LH-RH stimulation levels of LH, FSH and Testosterone (T) in 10 healthy, male volunteers, aged 24-35 years, and in 25 normogonadotropic oligospermic men aged 23-43 years in whom other endocrine, urologic and/or vascular diseases had been rules out. Seventeen of the latter group underwent bilateral testicular biopsy. Each subject received rapid i.v. injection of 50 mug synthetic LH-RH at 8:00 A.M. Serum levels of LH, FSH and T were determined by radioimmunoassay on samples obtained immediately before and 30 and 45 minutes after injection. As compared to normals, oligospermic men had a lower average LH response, although the basal values did not differ significantly from normal. FSH levels did not differ significantly between groups, although some individual patients showed higher and some lower than normal values. The possibility of stimulating T secretion with LH-RH was confirmed. Average serum T levels rose more slowly and reached lower levels in the oligospermic men than in normal men. There was no correlation between LH and FSH rises. It is postulated that some patients with normogonadotropic oligospermia may have latent insufficiency of pituitary gonadotropic functional reserve for one or both hormones and/or of the Leydig cell function. The need for individual analysis of results and their correlation with testicular biopsy findings is commented.
对10名年龄在24 - 35岁的健康男性志愿者以及25名年龄在23 - 43岁、促性腺激素正常的少精子症男性进行了比较研究，后者已排除其他内分泌、泌尿和/或血管疾病。后一组中有17人接受了双侧睾丸活检。每位受试者于上午8点静脉快速注射50微克合成促黄体生成素释放激素（LH - RH）。通过放射免疫分析法测定注射前即刻、注射后30分钟和45分钟采集的样本中LH、FSH和睾酮（T）的血清水平。与正常人相比，少精子症男性的LH平均反应较低，尽管基础值与正常人无显著差异。两组间FSH水平无显著差异，尽管部分个体患者的值高于或低于正常。证实了LH - RH刺激T分泌的可能性。少精子症男性的血清T平均水平升高更缓慢且达到的水平低于正常男性。LH和FSH升高之间无相关性。据推测，一些促性腺激素正常的少精子症患者可能存在一种或两种激素的垂体促性腺激素功能储备潜在不足和/或睾丸间质细胞功能不足。文中评论了对结果进行个体分析及其与睾丸活检结果相关性的必要性。
