马拉韦罗治疗缬更昔洛韦耐药巨细胞病毒视网膜炎的疗效。
EFFICACY OF MARIBAVIR IN VALGANCICLOVIR-RESISTANT CYTOMEGALOVIRUS RETINITIS.
机构信息
Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
出版信息
Retin Cases Brief Rep. 2024 Mar 1;18(2):164-167. doi: 10.1097/ICB.0000000000001372.
PURPOSE
To determine whether maribavir is effective at treating ganciclovir-resistant cytomegalovirus retinitis.
METHODS
Retrospective case report of a lung-transplant patient with bilateral cytomegalovirus retinitis documented with serum and aqueous humor studies and color fundus photographs.
RESULTS
A 72-year-old lung-transplant patient with active ganciclovir-resistant cytomegalovirus was treated with intravitreal foscarnet therapy in one eye. Retinitis developed in the contralateral eye and was managed with systemic maribavir alone. Active retinitis regressed in both the eye treated with intravitreal foscarnet and the uninjected eye.
CONCLUSION
This patient's results suggest that systemic maribavir is an effective treatment for treatment-resistant cytomegalovirus retinitis.
目的
确定马拉维若是否能有效治疗更昔洛韦耐药性巨细胞病毒视网膜炎。
方法
对一名肺移植患者双侧巨细胞病毒视网膜炎的血清和房水研究及眼底彩色照片进行回顾性病例报告。
结果
一名 72 岁的肺移植患者患有活动性更昔洛韦耐药性巨细胞病毒，一只眼接受玻璃体内膦甲酸治疗。对侧眼出现视网膜炎，仅接受全身马拉维若治疗。接受玻璃体内膦甲酸治疗的眼睛和未注射的眼睛的活动性视网膜炎均消退。
结论
该患者的结果表明，全身马拉维若是治疗耐药性巨细胞病毒视网膜炎的有效治疗方法。
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