Department of Organic Chemistry, Faculty of Chemical Sciences and Technologies, University of Castilla-La Mancha, 13071 Ciudad Real, Spain.
China-Canada Joint Lab of Food Nutrition and Health (Beijing), School of Food and Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China.
J Control Release. 2023 Mar;355:327-342. doi: 10.1016/j.jconrel.2023.01.069. Epub 2023 Feb 9.
The high prevalence of chronic illnesses, including cancer, diabetes, obesity, and cardiovascular diseases has become a growing concern for modern society. Recently, various bioactive compounds (bioactives) are shown to have a diversity of health-beneficial impacts on a wide range of disorders. But the application of these bioactives in food and pharmaceutical formulations is limited due to their poor water solubility and low bioaccessibility/bioavailability. Plant proteins are green alternatives for designing biopolymeric nanoparticles as appropriate nanocarriers thanks to their amphiphilic nature compatible with many bioactives and unique functional properties. Recently, emerging plant proteins (EPPs) are employed as nanocarriers for protection and targeted delivery of bioactives and also improving their stability and shelf-life. EPPs could enhance the solubility, stability, and bioavailability of bioactives by different types of delivery systems. In addition, the use of EPPs in combination with other biopolymers like polysaccharides was found to make a favorable wall material for food bioactives. This review article covers the various sources and importance of EPPs along with different encapsulation techniques of bioactives. Characterization of EPPs for encapsulation is also investigated. Furthermore, the focus is on the application of EPPs as nanocarriers for food bioactives.
慢性疾病（包括癌症、糖尿病、肥胖症和心血管疾病）的高发率已成为现代社会日益关注的问题。最近，各种生物活性化合物（生物活性物质）被证明对广泛的疾病具有多种有益的健康影响。但由于其水溶性差和生物利用度/生物可及性低，这些生物活性物质在食品和药物制剂中的应用受到限制。由于其两亲性质与许多生物活性物质相容，并且具有独特的功能特性，植物蛋白是设计生物聚合物纳米粒子的绿色替代品，作为合适的纳米载体。最近，新兴的植物蛋白（EPPs）被用作生物活性物质的保护和靶向递送的纳米载体，也提高了它们的稳定性和保质期。EPPs 可以通过不同类型的传递系统来提高生物活性物质的溶解度、稳定性和生物利用度。此外，研究发现，EPPs 与多糖等其他生物聚合物结合使用，是食品生物活性物质的一种有利的壁材。本文综述了 EPPs 的各种来源和重要性，以及生物活性物质的不同包封技术。还研究了 EPPs 用于封装的特性。此外，本文的重点是 EPPs 作为食品生物活性物质的纳米载体的应用。
