在接种第三剂 BNT162b2 单价疫苗后长达六个月的日本医护人员体液和细胞免疫应答动态。
Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine.
机构信息
Department of Laboratory Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
出版信息
Vaccine. 2023 Feb 24;41(9):1545-1549. doi: 10.1016/j.vaccine.2023.01.049. Epub 2023 Jan 31.
Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.
关于 COVID-19 疫苗接种后第一针到第三针后几个月的免疫反应的纵向数据有限。我们分析了至少接种三剂疫苗的 406 名日本医护人员的免疫反应。第三剂接种后 6 个月时的受体结合域 IgG 抗体几何平均滴度和抗原刺激的 T 细胞干扰素-γ水平与第二剂接种后 8 周时相似。第三剂引起的体液和细胞免疫比第二剂更持久。UMIN 临床试验注册 ID：UMIN000043340。
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