鸢尾素表达与伴有或不伴有 CAD 的 2 型糖尿病患者的(rs3480)基因多态性。
Irisin expression and (rs3480) gene polymorphism in type 2 diabetic patients with and without CAD.
机构信息
Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.
出版信息
Arch Physiol Biochem. 2024 Oct;130(5):523-528. doi: 10.1080/13813455.2023.2173785. Epub 2023 Feb 2.
BACKGROUND
Irisin was found to correlate with coronary artery disease (CAD) in diabetic patients. This study investigated the association of irisin and (SNP rs3480) with the presence and severity of CAD in T2DM.
METHODS
This cross-sectional study included 100 patients with T2DM divided into two groups, DM group ( = 50), including patients without CAD and CAD group ( = 50), including those confirmed to have CAD by coronary angiography. Irisin was measured. SNP rs3480 genotyping of was done.
RESULTS
Irisin levels were significantly lower in the CAD group ( < 0.001). The CAD group had significantly higher HbA1c and lower HDL ( < 0.001). Patients with controlled DM had significantly higher irisin levels ( < 0.001). single nucleotide polymorphism (SNP) rs3480 was not associated with irisin levels, and the rs3480 AA reference allele was significantly associated with significant CAD.
CONCLUSION
Irisin appears to be protective against developing CAD in diabetic patients. Irisin level was an independent predictor of significant CAD in diabetic patients combined with the rs3480 genotype.
CLINICAL TRIAL REGISTRATION NUMBER
NCT04957823.
背景
鸢尾素与糖尿病患者的冠状动脉疾病（CAD）相关。本研究探讨了鸢尾素与（SNP rs3480）与 T2DM 患者 CAD 的存在和严重程度的相关性。
方法
这项横断面研究纳入了 100 名 T2DM 患者，分为两组，DM 组（n=50），包括无 CAD 的患者，CAD 组（n=50），包括经冠状动脉造影证实有 CAD 的患者。测量鸢尾素水平。对进行 SNP rs3480 基因分型。
结果
CAD 组鸢尾素水平显著降低（P<0.001）。CAD 组的 HbA1c 显著升高，HDL 显著降低（P<0.001）。血糖控制良好的患者鸢尾素水平显著升高（P<0.001）。单核苷酸多态性（SNP）rs3480 与鸢尾素水平无关，而 rs3480 AA 参考等位基因与严重 CAD 显著相关。
结论
鸢尾素似乎对糖尿病患者发生 CAD 有保护作用。鸢尾素水平是糖尿病患者发生严重 CAD 的独立预测因子，与 rs3480 基因型相结合。
临床试验注册号
NCT04957823。
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