Shimojima Yukio, Nomura Tatsuya, Takano Kabuto, Nakayasu Yasuyo, Kono Teppei, Kuhara Kotaro, Usui Takebumi, Asaka Shinichi, Yokomizo Hajime, Shimakawa Takeshi, Ohigashi Seiji, Shiozawa Shunichi
Dept. of Digestive Surgery, Niigata Cancer Center Hospital.
Gan To Kagaku Ryoho. 2022 Dec;49(13):1662-1664.
We report a case of resectable pancreas tail cancer treated with 2 courses of neoadjuvant therapy which is gemcitabine and S-1 therapy, and pathological diagnosis of the resected specimen revealed pathological complete response. A 56-year- old woman was referred to our hospital because she had back pain after eating for 5 months and her previous abdominal ultrasonography revealed an enlarged pancreatic tail. The tumor size was reduced from 30 mm to 12 mm, and the chemotherapy response was judged to be partial response. The patient underwent distal pancreatectomy, splenectomy, and D2 lymph node dissection. Intraoperative findings showed a pancreatic tail with a depression and surface erythema, thus we also diagnosed the patient as having pancreatic capsular invasion(S1). Postoperative histopathological examination revealed a 10×10 mm area of pancreatic parenchyma, which was replaced by fibrous tissue, with no evidence of active cancer cells. The patient was discharged from the hospital on the 14th after surgery.
我们报告了一例可切除的胰尾癌患者，其接受了2个疗程的新辅助治疗，即吉西他滨和S-1治疗，切除标本的病理诊断显示为病理完全缓解。一名56岁女性因进食后背痛5个月前来我院就诊，其先前的腹部超声检查显示胰尾肿大。肿瘤大小从30毫米缩小至12毫米，化疗反应被判定为部分缓解。患者接受了胰体尾切除术、脾切除术和D2淋巴结清扫术。术中发现胰尾有凹陷和表面红斑，因此我们也诊断该患者存在胰腺被膜侵犯（S1）。术后组织病理学检查显示，10×10毫米的胰腺实质区域被纤维组织取代，未发现活跃癌细胞。患者术后第14天出院。
