Yin Ya-Nan, Xie Hong, Ren Jian-Hua, Jiang Ni-Jie, Dai Li
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China.
West China School of Nursing, Sichuan University, Chengdu, China.
Front Oncol. 2023 Jan 17;12:1059924. doi: 10.3389/fonc.2022.1059924. eCollection 2022.
To assess the effect and safety of gum-chewing on the prevention of postoperative ileus after gynecological cancer surgery.
We conducted a systematic review of randomized controlled trials (RCTs) published between 2000 and 2022 in English and Chinese, using the EBSCO, Web of Science, Scopus, Cochrane Central Register of Controlled Trials (Cochrane database), PubMed, Medline (via Ovid), Chinese National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, and Wan Fang databases. A total of 837 studies were screened using Endnote software, and those that met the inclusion criteria were selected for analysis. The main outcome of interest was the incidence of postoperative ileus, and secondary outcomes included time to first flatus, time to first bowel movement, and length of hospital stay.
Two authors extracted data and performed quality assessment independently. The review included six RCTs with a total of 669 patients. Compared with routine care, gum-chewing could significantly reduce the incidence of postoperative ileus (RR 0.46, 95% CI: 0.30, 0.72, P=0.0006), shorten the time to first flatus (WMD -9.58, 95% CI: -15.04, -4.12, =0.0006), first bowel movement (WMD -11.31, 95% CI: -21.05, -1.56, =0.02), and the length of hospital stay (WMD -1.53, 95% CI: -2.08, -0.98, <0.00001).
Gum-chewing is associated with early recovery of gastrointestinal function after gynecological cancer surgery and may be an effective and harmless intervention to prevent postoperative ileus.
https://www.crd.york.ac.uk/prospero/#searchadvanced, identifier CRD42022384346.
评估咀嚼口香糖对预防妇科癌症手术后肠梗阻的效果及安全性。
我们对2000年至2022年间以英文和中文发表的随机对照试验（RCT）进行了系统评价，使用了EBSCO、科学网、Scopus、Cochrane对照试验中心注册库（Cochrane数据库）、PubMed、Medline（通过Ovid）、中国知网、中国科技期刊数据库和万方数据库。使用Endnote软件共筛选出837项研究，选择符合纳入标准的研究进行分析。主要关注的结局是术后肠梗阻的发生率，次要结局包括首次排气时间、首次排便时间和住院时间。
两位作者独立提取数据并进行质量评估。该评价纳入了6项RCT，共669例患者。与常规护理相比，咀嚼口香糖可显著降低术后肠梗阻的发生率（RR 0.46，95%CI：0.30，0.72，P = 0.0006），缩短首次排气时间（WMD -9.58，95%CI：-15.04，-4.12，P = 0.0006）、首次排便时间（WMD -11.31，95%CI：-21.05，-1.56，P = 0.02）以及住院时间（WMD -1.53，95%CI：-2.08，-0.98，P < 0.00001）。
咀嚼口香糖与妇科癌症手术后胃肠功能的早期恢复有关，可能是预防术后肠梗阻的一种有效且无害的干预措施。
https://www.crd.york.ac.uk/prospero/#searchadvanced，标识符CRD42022384346。
