Department of Small Animal Clinical Sciences (Williams, MacDonald-Dickinson), Department of Large Animal Clinical Sciences (Parker), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
Can Vet J. 2023 Feb;64(2):167-173.
Risk factors for the development of canine appendicular osteosarcoma (OSA) have been investigated in numerous studies, but with contradictory results. The aim of this study was to analyze weight, age, breed, sex, neuter status, body condition score, and previous lameness in a population of large and giant breed dogs in western Canada with and without appendicular OSA.
Medical records of 227 large or giant breed dogs diagnosed with appendicular OSA were compared to records from a control population of 454 large and giant breed dogs from the years 2000 to 2020.
Gonadectomized dogs, body condition score (BCS), and a history of lameness condition(s) (other than OSA) were associated with increased odds for presentation with OSA. Breeds shown to have increased odds for appendicular OSA occurrence included Rottweilers and Great Danes relative to Labrador retrievers.
Obesity and lameness appear to be independently associated with appendicular osteosarcoma. This study demonstrated that spayed females had the greatest risk compared to other sex and neuter status combinations; further investigation of these factors would be beneficial.
许多研究已经调查了犬附肢骨肉瘤（OSA）发展的危险因素，但结果存在矛盾。本研究旨在分析加拿大西部大型和巨型犬种中有无附肢 OSA 的犬只的体重、年龄、品种、性别、绝育状态、身体状况评分和先前跛行情况。
对 227 只诊断为附肢 OSA 的大型或巨型犬的病历与 2000 年至 2020 年期间来自 454 只大型和巨型犬的对照组记录进行了比较。
去势犬、身体状况评分（BCS）和跛行病史（除 OSA 以外的其他疾病）与 OSA 就诊的可能性增加有关。与拉布拉多猎犬相比，表现出增加的附肢 OSA 发生几率的品种包括罗特韦尔犬和大丹犬。
肥胖和跛行似乎与附肢骨肉瘤独立相关。本研究表明，与其他性别和绝育状态组合相比，雌性去势犬的风险最大；进一步研究这些因素将是有益的。
