Department of Ophthalmology, Peking University First Hospital, Beijing, China.
Front Endocrinol (Lausanne). 2023 Jan 17;13:1036735. doi: 10.3389/fendo.2022.1036735. eCollection 2022.
To explore intraretinal blood flow perfusion and nerve changes, as well as the correlation between them, in diabetic patients without diabetic retinopathy (NDR).
Eighty-six NDR patients (86 eyes) who attended the ophthalmology clinic between December 2019 and December 2021 were included. Sixty-four eyes of 64 healthy examined controls in the same period were selected as the control group. The patients underwent routine ophthalmological examination, optical coherence tomography (OCT) and OCT angiography.
The average thickness, minimum thickness and thickness of each quadrant except for the superior temporal quadrant of the ganglion cell-inner plexiform layer (GCIPL) in the macular area of the affected eyes in the NDR group were lower than that of the tested eyes in the control group ( < 0.05). The average retinal nerve fibre layer (RNFL) thickness of the NDR group and the superior, inferior and nasal quadrants around the optic disc of the affected eyes in the NDR group were lower compared with the tested eyes in the control group ( < 0.001, 0.003, = 0.001, = 0.009). The mean vessel length density in the parafoveal and perifoveal areas in the NDR group was positively associated with the mean GCIPL thickness in the macular area ( = 0.265, = 0.257 and < 0.001). No blood flow perfusion parameters in the NDR group were correlated with the RNFL thickness of the corresponding quadrant around the optic disc ( > 0.05).
In diabetic patients without diabetic retinopathy, the superficial retinal vessel density in the macular area positively correlated with GCIPL thickness, and the superficial retinal vessel density around the optic disc was not correlated with RNFL thickness.
探讨无糖尿病视网膜病变（NDR）的糖尿病患者的视网膜内血流灌注和神经变化及其相关性。
选取 2019 年 12 月至 2021 年 12 月在我院眼科门诊就诊的 86 例 NDR 患者（86 只眼）为观察组，同期选取 64 例健康体检者的 64 只眼作为对照组。所有患者均行常规眼科检查、光学相干断层扫描（OCT）及 OCT 血管造影检查。
观察组患眼黄斑区各象限（除外颞上象限）神经节细胞-内丛状层（GCIPL）平均厚度、最小厚度及厚度均低于对照组（ < 0.05）。观察组患眼平均视网膜神经纤维层（RNFL）厚度及视盘周围上方、下方和鼻侧象限均低于对照组（ < 0.001、 < 0.003、 = 0.001、 = 0.009）。观察组患眼黄斑区 GCIPL 厚度与中心凹旁和中心凹周围 1mm 区平均血管长度密度呈正相关（ = 0.265、 = 0.257、 < 0.001）。观察组各象限的血流灌注参数与相应象限的 RNFL 厚度均无相关性（ > 0.05）。
无糖尿病视网膜病变的糖尿病患者黄斑区浅层视网膜血管密度与 GCIPL 厚度呈正相关，而视盘周围浅层视网膜血管密度与 RNFL 厚度无相关性。
