Department of Obstetrics and Gynecology, Seoul Saint Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Department of Obstetrics and Gynecology, Saint Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
J Int Med Res. 2023 Feb;51(2):3000605221098177. doi: 10.1177/03000605221098177.
This report describes a woman with a rare primary squamous cell carcinoma of the ovary accompanied by transition of a mucinous borderline ovarian tumor. A woman in her late 40s was referred for abdominal discomfort, which worsened during defecation. Pelvic magnetic resonance imaging showed a multiloculated cystic lesion in the left adnexa measuring approximately 7.5 × 9.5 × 7.0 cm. An intraoperatively obtained frozen biopsy sample of the mass in the left ovary was positive for malignancy, resulting in a surgical staging operation. The tumor was composed of squamous cell carcinoma and mucinous borderline tumor. There was no evidence of capsular invasion or invasion of other internal organs, including pelvic and para-aortic lymph nodes (0/41). Immunohistochemistry showed that the tumor was diffusely positive for cytokeratin 7, cytokeratin 20, Ki-67, and P40 but negative for P16. After a debulking operation, the patient has been monitored regularly without adjuvant therapy owing to final surgical staging of the tumor as stage IA.
本报告描述了一例罕见的卵巢原发性鳞状细胞癌伴交界性黏液性卵巢肿瘤转化。一名 40 多岁的女性因排便时加重的腹部不适就诊。盆腔磁共振成像显示左侧附件有一个多房囊性病变，大小约为 7.5×9.5×7.0cm。左卵巢肿块的术中冷冻活检样本为恶性，行手术分期手术。肿瘤由鳞状细胞癌和交界性黏液性肿瘤组成。未见包膜侵犯或其他内部器官侵犯，包括盆腔和腹主动脉旁淋巴结（0/41）。免疫组化显示肿瘤弥漫性表达细胞角蛋白 7、细胞角蛋白 20、Ki-67 和 P40，但不表达 P16。在减瘤手术后，由于肿瘤最终的手术分期为 IA 期，患者未接受辅助治疗，定期进行监测。
