Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland.
Folia Neuropathol. 2022;60(4):375-383. doi: 10.5114/fn.2022.123500.
Tumour-to-meningioma metastasis (TTMM) is an uncommon phenomenon, however repeatedly found in the literature. Meningiomas occur to be the most frequent target of metastatic expansion of systemic cancers. Meningiomas often vary in symptoms and treatment, and this largely depends on the tumour location. Due to their variable locations, they can be classified as convexity meningiomas, which includes falcine and parasagittal tumours, and cranial base, which includes tumours located in the olfactory groove, sphenoid wing, petrous bone and other cranial base locations. The aim of this study was to analyse all data regarding metastases to cranial base meningiomas. We performed a literature search to locate all cases of metastases to cranial base meningiomas in PubMed and Medline databases using the following key words: metastasis to meningioma, meningioma metastasis, and cranial base meningioma. We collected patient and cancer parameters, exact meningioma location and clinical presentations including characteristics which may suggest TTMM. We found 100 articles describing 111 patients of metastasis to cranial base meningioma. Among these articles, 55 cases (49.55%) included metastases to non-skull base meningiomas. In 24 cases (21.62%), the location of meningioma was not precisely described or other data were unavailable, in particular histopathological examination. The most common location of TTMM was sphenoid wing, which was found in 9 patients. The other locations included cerebellopontine angle in 5 patients, and tuberculum sellae in 3 cases. 81.25% cases of TTMM were reported in women, and the most common cancer origins were the breast (28.3%), lung (18.7%), kidney (9.38%) and prostate (9.38%). In two cases the metastatic origin was unclear, and in 15.6% of cases the patients were in remission for more than 1 year. In 78.1% of cases patients presented focal deficits, followed by increased intracranial pressure, and seizures. In almost one-third of cases, TTMM first appeared from a previously unknown cancer. Rapid clinical presentation of cranial nerve palsies may suggest the dual nature of intracranial pathology. The metastasis to cranial base meningioma should be suspected in patients with oncological background, regardless of meningioma parameters or cancer status.
肿瘤脑膜瘤转移（TTMM）是一种罕见的现象，但在文献中反复出现。脑膜瘤是全身癌症转移扩散的最常见靶标。脑膜瘤的症状和治疗方法多种多样，这在很大程度上取决于肿瘤的位置。由于它们的位置不同，脑膜瘤可以分为凸面脑膜瘤，包括镰状和矢状旁肿瘤，以及颅底，包括位于嗅沟、蝶骨翼、岩骨和其他颅底部位的肿瘤。本研究的目的是分析所有关于颅底脑膜瘤转移的资料。我们在 PubMed 和 Medline 数据库中使用以下关键词进行了文献检索，以查找所有关于颅底脑膜瘤转移的病例：脑膜瘤转移、脑膜瘤转移和颅底脑膜瘤，以找到颅底脑膜瘤转移的所有病例。我们收集了患者和癌症参数、确切的脑膜瘤位置以及包括可能提示 TTMM 的特征在内的临床表现。我们发现了 100 篇描述 111 例颅底脑膜瘤转移的文章。在这些文章中，55 例（49.55%）包括非颅底脑膜瘤转移。在 24 例（21.62%）中，脑膜瘤的位置没有详细描述或其他数据不可用，特别是组织病理学检查。TTMM 最常见的部位是蝶骨翼，有 9 例。其他部位包括 5 例桥小脑角，3 例鞍结节。81.25%的 TTMM 发生在女性，最常见的癌症来源是乳腺（28.3%）、肺（18.7%）、肾（9.38%）和前列腺（9.38%）。在 2 例中，转移的起源尚不清楚，在 15.6%的病例中，患者缓解时间超过 1 年。在 78.1%的病例中，患者表现为局灶性缺陷，其次是颅内压升高和癫痫发作。在近三分之一的病例中，TTMM 首先出现在以前未知的癌症中。颅神经麻痹的快速临床表现可能提示颅内病变的双重性质。无论脑膜瘤参数或癌症状态如何，对于有肿瘤学背景的患者，都应怀疑颅底脑膜瘤转移。
