Sættem Magnus, Sundstrøm Terje, Sæle Anna K Myrmel, Mahesparan Rupavathana
Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.
Department of Biomedicine, University of Bergen, Bergen, Norway.
Brain Spine. 2024 Jul 6;4:102862. doi: 10.1016/j.bas.2024.102862. eCollection 2024.
A tumor-to-tumor metastasis (TTM) is a rare metastatic process where a primary malignant tumor metastasizes to another tumor, most commonly a benign tumor such as a meningioma. Here, we present two recent cases of tumor-to-meningioma metastases (TMM) from our clinical practice and review of recent literature. The primary cancers were prostate and breast cancer, respectively.
We reviewed the electronic medical records of the two patients and conducted a literature review of TTM, focusing on biological mechanisms related to TMM.
Our first patient, a man with a history of stable prostate cancer, underwent resection of two WHO grade 1 meningiomas, and the largest tumor was found to have TMM. Our second patient, a woman with progressive breast cancer, was operated for a WHO grade II meningioma, and the meningioma harbored breast cancer metastases. TMM is a rare occurrence, but breast cancer is a much more frequent cause than prostate cancer and we reviewed 50 cases. Only 15 of cases of TMM from prostate cancer have been described.
TMM is a rare phenomenon, but it is important to be aware of this as more and more patients live with cancer and meningiomas have a high prevalence, The possibility of TMM may impact not only both the surgical and oncological treatment but also surveillance of incidental meningiomas.
肿瘤至肿瘤转移（TTM）是一种罕见的转移过程，即原发性恶性肿瘤转移至另一个肿瘤，最常见的是转移至如脑膜瘤这样的良性肿瘤。在此，我们介绍两例近期来自我们临床实践的肿瘤至脑膜瘤转移（TMM）病例，并回顾近期文献。原发性癌症分别为前列腺癌和乳腺癌。
我们查阅了这两名患者的电子病历，并对TTM进行了文献回顾，重点关注与TMM相关的生物学机制。
我们的首例患者是一名有稳定前列腺癌病史的男性，接受了切除两个世界卫生组织1级脑膜瘤的手术，发现最大的肿瘤存在TMM。我们的第二例患者是一名患有进展性乳腺癌的女性，因世界卫生组织2级脑膜瘤接受手术，该脑膜瘤存在乳腺癌转移。TMM较为罕见，但乳腺癌是比前列腺癌更常见的病因，我们回顾了50例病例。仅有15例前列腺癌导致的TMM病例被描述过。
TMM是一种罕见现象，但随着越来越多的癌症患者存活且脑膜瘤患病率较高，了解这一点很重要。TMM的可能性不仅可能影响手术和肿瘤治疗，还可能影响对偶然发现的脑膜瘤的监测。
