Tomaszewski J, Zwierz K, Musiatowicz B, Jezyna C
1st Department of Laboratory Diagnostics, District Hospital, Białystok, Poland.
Acta Biol Hung. 1986;37(2):121-8.
Forty male guinea-pigs weighing 400-600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed congestion and obliteration of the trabecular structure of the liver. Acidophilic and vacuolar degeneration of the liver cells with signs of necrosis were also observed. Histochemical tests revealed a poorer staining for glycogen and succinic dehydrogenase and intensification of the alkaline and acid phosphatases reaction. The above findings indicate a progressive degeneration due to metribuzin of different organelles of the liver cells including nuclei, mitochondria, lysosomes, microvilli and the cytoplasm.
40只体重400 - 600克、8月龄的雄性豚鼠，在30天内（20只动物）或90天内（20只动物），每周6次直接将嗪草酮注入胃腔。中毒动物表现出肝脏小梁结构充血和闭塞。还观察到肝细胞嗜酸性和空泡变性并有坏死迹象。组织化学测试显示糖原和琥珀酸脱氢酶染色较差，碱性和酸性磷酸酶反应增强。上述发现表明嗪草酮导致肝细胞包括细胞核、线粒体、溶酶体、微绒毛和细胞质等不同细胞器进行性变性。
