Zwierz K, Tomaszewski J, Rózański A, Kreczko S
Acta Biol Acad Sci Hung. 1981;32(1):69-73.
Forty male guinea pigs weighting 400--600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed in the gastric mucosa a significant decrease in glucosamine isomerase activity and a significant increased in beta-glucosidase and beta-galactosidase activity. The results suggest that the biosynthesis of the sugar moiety of glycoproteins is depressed, the degradation of glycoproteins is stimulated by metribuzin.
40只体重400 - 600克、8月龄的雄性豚鼠，在30天内（20只动物）或90天内（20只动物）每周6次经胃腔直接给予甲草嗪。中毒动物的胃黏膜中氨基葡萄糖异构酶活性显著降低，β - 葡萄糖苷酶和β - 半乳糖苷酶活性显著升高。结果表明，甲草嗪抑制了糖蛋白糖部分的生物合成，刺激了糖蛋白的降解。
